Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 3/20 | 0.64 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.61 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.61 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.59 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | PLG | P00747 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | PLAT | P00750 | 1/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3658561 | 0.94 | F2 (0.57) | MELKITGB3ITGA2BSLC2A1ITGA2 | |
| Hydrochloric Acid SCHEMBL18491400 | 0.92 | ITGB3 (0.56) | MELKITGB3ITGA2BSLC2A1ITGA2 | |
| SCHEMBL17797501 | 0.91 | MELK (0.54) | MELKITGB3ITGA2BSLC2A1ITGA2 | |
| SCHEMBL12501320 | 0.86 | ITGB3 (0.58) | ITGB3ITGA2B | |
| SCHEMBL31174281 | 0.86 | MELK (0.63) | MELKITGB3ITGA2BSLC2A1ITGA2 | |
| SCHEMBL8117385 | 0.86 | MELK (0.63) | MELKITGB3ITGA2BSLC2A1ITGA2 | |
| SCHEMBL3891388 | 0.86 | MELK (0.63) | MELKITGB3ITGA2BSLC2A1ITGA2 | |
| SCHEMBL17797703 | 0.84 | NPC1 (0.50) | MELKITGB3ITGA2BF2PLG | |
| SCHEMBL24892142 | 0.84 | MELK (0.87) | MELKITGB3ITGA2BSLC2A1ITGA2 | |
| SCHEMBL29431209 | 0.84 | MELK (0.76) | MELKITGB3ITGA2BSLC2A1ITGA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002520-A2 | SMALL MOLECULE INHIBITORS OF PARP ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2011-01-06 | — | — | WO | claimed |