ITGB3

Integrin beta-3 · P05106 · ITGB3 on Sugi Atlas →

193,521 patent compounds predicted against ITGB3, 100,065 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Tirofiban (SCHEMBL3685)	1.00	20/20
Lotrafiban (SCHEMBL29596)	1.00	20/20
SCHEMBL244300	1.00	20/20
SCHEMBL244675	1.00	20/20
SCHEMBL244700	1.00	20/20
SCHEMBL245523	1.00	20/20
Tirofiban (SCHEMBL41327)	0.98	20/20
Tirofiban (SCHEMBL155170)	0.98	20/20
Tirofiban (SCHEMBL41325)	0.96	20/20
Tirofiban (SCHEMBL140366)	0.96	20/20
Tirofiban (SCHEMBL41326)	0.95	20/20
SCHEMBL244091	0.91	20/20
Roxifiban (SCHEMBL50632)	0.86	20/20
SCHEMBL246301	0.81	20/20
Cilengitide (SCHEMBL34082)	0.78	20/20
SCHEMBL244092	0.68	20/20
SCHEMBL243035	0.61	20/20
SCHEMBL243383	1.00	19/20
Lamifiban (SCHEMBL4683)	1.00	17/20
SCHEMBL244383	1.00	17/20

Clinical trials — most relevant to ITGB3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Outcomes of ICSI Cycles With and Without Letrozole	PHASE4	UNKNOWN
The Use of 18F-ALF-NOTA-PRGD2 PET/CT Scan to Predict the Efficacy and Adverse Events of Apatinib in Malignancies.	PHASE4	COMPLETED
99mTc-3PRGD2 SPECT/CT for Integrin Imaging of Lung Cancer	PHASE3	COMPLETED
Monoclonal Antibody Therapy in Treating Patients With Advanced Colorectal Cancer	PHASE1/PHASE2	COMPLETED
68 Ga-NODAGA-E[c(RGDγK)]2: Positron Emission Tomography Tracer for Imaging of Myocardial Angiogenesis	PHASE2	COMPLETED
68 Ga-NODAGA-E[c(RGDγK)]2: Positron Emission Tomography Tracer for Imaging of Angiogenesis in Ischemic Heart Disease	PHASE2	UNKNOWN
A Gene Therapy Trial to Evaluate the Safety and Efficacy of RP-L201 in Subjects With Leukocyte Adhesion Deficiency-I	PHASE1	WITHDRAWN
Safety/Biomarker Study of CNTO 95 and Avastin in Solid Tumors	PHASE1	COMPLETED
68Ga-BNOTA-PRGD2 PET/CT in Patients With Rheumatoid Arthritis	EARLY_PHASE1	UNKNOWN
68Ga-NOTA-PRGD2 PET/CT in Patients With Lung Injury and Pulmonary Fibrosis	EARLY_PHASE1	UNKNOWN
68Ga-BNOTA-PRGD2 PET/CT in Diagnosis and Evaluation of Glioma	EARLY_PHASE1	UNKNOWN
68Ga-BNOTA-PRGD2 PET/CT in Evaluation of Stroke	EARLY_PHASE1	UNKNOWN
68Ga-BNOTA-PRGD2 PET/CT in Evaluation of Myocardial Infarction	EARLY_PHASE1	UNKNOWN
68Ga-BNOTA-PRGD2 PET/CT in Healthy Volunteers and Lung Cancer Patients	EARLY_PHASE1	UNKNOWN
99mTc-3PRGD2 SPECT/CT in Rheumatoid Arthritis Patients	EARLY_PHASE1	COMPLETED
177Lu-AB-3PRGD2 in Patients With Integrin αVβ3 Positive Tumors	EARLY_PHASE1	RECRUITING
99mTc-3PRGD2 SPECT/CT in Esophagus Cancer Patients	EARLY_PHASE1	COMPLETED
99mTc-3PRGD2 SPECT/CT in Lung Cancer Patients	EARLY_PHASE1	UNKNOWN
Anti-αIIbβ3 Immunization in Glanzmann Thrombasthenia: Prevalence and Associated Risk Factors: Thrombasthenia Anti-αIIbβ3 Antibodies Study (TAAS)	nan	COMPLETED
Clinical Study of 18F-FAPI-RGD in Breast Tumors	nan	COMPLETED
Clinical Study of 18F-FAPI-RGD in Ovarian Cancer	nan	COMPLETED
Angiogenesis and Fibrosis in Aortic Stenosis	nan	COMPLETED
ITGA2b and SELP Expression in Cancer Pancreas and Biliary Tract Cancer	nan	UNKNOWN
Angiogenesis and Fibrosis in Myocardial Infarction	nan	COMPLETED
Interaction Between HIV and Platelets	nan	UNKNOWN
68Ga-NODAGA-RGD PET in Patients With an Occluded Coronary Artery	nan	UNKNOWN
Integrin αvβ6-targeted PET in Malignant Tumors	nan	RECRUITING
99mTc-3PRGD2 SPECT/CT in Breast Cancer Patients	nan	COMPLETED
Identification of Integrin ab Expression in Lung Cancer Patients	nan	COMPLETED
The Role of CD4+ T Cell Subsets in the Mechanism of Action of Vedolizumab in Ulcerative Colitis	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ITGB3 binder may also engage these)

Protein	Name	Similarity
O70309	—	1.000	O70309 →
O54890	—	1.000	O54890 →
ITGB5	Integrin beta-5	0.998	landscape →
P80747	—	0.996	P80747 →
Q8R2H2	—	0.996	Q8R2H2 →
Q07441	—	0.993	Q07441 →
Q0VBD0	—	0.982	Q0VBD0 →
Q6AYF4	—	0.980	Q6AYF4 →
ITGB6	Integrin beta-6	0.979	landscape →
P18563	—	0.978	P18563 →
Q1RPR6	—	0.978	Q1RPR6 →
Q8SQB8	—	0.976	Q8SQB8 →
Q863C4	—	0.975	Q863C4 →
Q9Z0T9	—	0.975	Q9Z0T9 →
P26013	—	0.974	P26013 →
Q9HCM2	—	0.973	Q9HCM2 →
Q6BEA0	—	0.973	Q6BEA0 →
A8MWY0	—	0.973	A8MWY0 →
Q80UG2	—	0.971	Q80UG2 →
Q3UZV7	—	0.971	Q3UZV7 →
Q9QX15	—	0.969	Q9QX15 →
Q8R4G0	—	0.968	Q8R4G0 →
Q9Y2I2	—	0.968	Q9Y2I2 →
Q62469	—	0.967	Q62469 →
ITGB8	Integrin beta-8	0.967	landscape →
O75051	—	0.967	O75051 →
Q13797	—	0.966	Q13797 →
P26009	—	0.966	P26009 →
ITGA8	Integrin alpha-8 [Cleaved into: Integrin alph	0.966	landscape →
A7E2Z9	—	0.965	A7E2Z9 →