Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CDC25B | P30305 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL259073 | 0.79 | ALDH1A1 (0.52) | AKR1C3MAPTALDH1A1TDP1PKM | |
| SCHEMBL27581063 | 0.78 | AKR1C3 (0.48) | AKR1C3MAPTGAAALDH1A1TDP1 | |
| SCHEMBL29447165 | 0.78 | AKR1C3 (0.85) | AKR1C3MAPTGAAALDH1A1TDP1 | |
| SCHEMBL700595 | 0.78 | AKR1C3 (0.85) | AKR1C3MAPTGAAALDH1A1TDP1 | |
| Fluoride SCHEMBL28319246 | 0.75 | AKR1C3 (0.81) | AKR1C3MAPTGAAALDH1A1TDP1 | |
| SCHEMBL28883310 | 0.75 | AKR1C3 (0.81) | AKR1C3MAPTGAAALDH1A1TDP1 | |
| SCHEMBL3953437 | 0.75 | ALDH1A1 (0.73) | MAPTGAAALDH1A1TDP1NPSR1 | |
| SCHEMBL29163962 | 0.73 | AKR1C3 (0.77) | AKR1C3MAPTGAAALDH1A1TDP1 | |
| Ethylene SCHEMBL27279241 | 0.73 | AKR1C3 (0.77) | AKR1C3MAPTGAAALDH1A1TDP1 | |
| SCHEMBL1981395 | 0.72 | ALDH1A1 (0.47) | MAPTALDH1A1NPSR1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9085575-B2 | Tri- and tetracyclic pyrazolo[3,4-B]pyridine compounds as antineoplastic agent | PIERRE FABRE MEDICAMENT (FR) | 2015-07-21 | — | — | US | disclosed |
| EP-2697222-A1 | TRI- AND TETRACYCLIC PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS ANTINEOPLASTIC AGENT | Pierre Fabre Medicament (FR) | 2014-02-19 | — | — | EP | disclosed |
| US-20140031362-A1 | TRI - AND TETRACYCLIC PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS ANTINEOPLASTIC AGENT | PIERRE FABRE MEDICAMENT (FR) | 2014-01-30 | — | — | US | disclosed |
| WO-2012140114-A1 | TRI- AND TETRACYCLIC PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS ANTINEOPLASTIC AGENT | PIERRE FABRE MEDICAMENT (FR) | 2012-10-18 | — | — | WO | disclosed |
| US-4964896-A | GAMETOCIDES | MONSANTO COMPANY (US) | 1990-10-23 | — | — | US | disclosed |
| US-4936904-A | Aryl-4-oxonicotinates useful for inducing male sterility in cereal grain plants | MONSANTO TECHNOLOGY LLC | 1990-06-26 | — | — | US | disclosed |
| EP-0127313-B1 | THE PRODUCTION OF HAPLOID SEED, OF DOUBLED HAPLOIDS AND OF HOMOZYGOUS PLANT LINES THEREFROM | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1989-07-19 | — | — | EP | disclosed |
| US-4714492-A | HYBRIDIZATION AGENTS | ROHM AND HAAS COMPANY (US) | 1987-12-22 | — | — | US | disclosed |
| EP-0127313-A1 | The production of haploid seed, of doubled haploids and of homozygous plant lines therefrom | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1984-12-05 | — | — | EP | disclosed |
| EP-0040082-B1 | NOVEL SUBSTITUTED OXONICOTINATES, THEIR USE AS PLANT GROWTH REGULATORS AND PLANT GROWTH REGULATING COMPOSITIONS CONTAINING THEM | ROHM AND HAAS COMPANY (US) | 1984-04-25 | — | — | EP | disclosed |
| EP-0040082-A1 | Novel substituted oxonicotinates, their use as plant growth regulators and plant growth regulating compositions containing them | ROHM AND HAAS COMPANY (US) | 1981-11-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031362-A1 | TRI - AND TETRACYCLIC PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS ANTINEOPLASTIC AGENT | TPMT, TYMP, PAICS | AKR1C3 465/4885MAPT 433/4885GAA 2511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.