Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.70 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.70 |
| ▸ | MAOA | P21397 | 1/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.70 |
| ▸ | F10 | P00742 | 2/20 | 0.66 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.64 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10463324 | 0.99 | PDE3B (0.68) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10460683 | 0.92 | GPR119 (0.62) | PDE3BPDE3AABCB11MAOAADORA2A | |
| Hydrochloric Acid SCHEMBL10463323 | 0.91 | GPR119 (0.61) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL9781456 | 0.86 | PDE3B (0.77) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10769323 | 0.85 | PDE3B (0.72) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL8264681 | 0.84 | PDE3B (0.77) | PDE3BPDE3AABCB11MAOAADORA2A | |
| Hydrochloric Acid SCHEMBL11290551 | 0.83 | PDE3B (0.76) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10770230 | 0.82 | PDE3B (0.68) | PDE3BPDE3AABCB11MAOAADORA2A | |
| Pimobendan SCHEMBL1649737 | 0.82 | PDE3B (1.00) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL7714090 | 0.81 | PDE3B (0.73) | PDE3BPDE3AABCB11MAOAADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4923869-A | INOTROPIC, VASODILATING, AND ANTITHROMBOTIC AGENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-05-08 | — | — | US | claimed |
| EP-0193013-B1 | BENZIMIDAZOLYL-PYRIDAZINONES | MERCK PATENT GmbH (DE) | 1989-04-19 | — | — | EP | claimed |
| EP-0193013-B1 | BENZIMIDAZOLYL-PYRIDAZINONES | MERCK PATENT GmbH (DE) | 1989-04-19 | — | — | EP | disclosed |
| EP-0196005-A1 | Pyridazinones, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1986-10-01 | — | — | EP | disclosed |