Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 5/20 | 0.44 |
| ▸ | AKT2 | P31751 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 6/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1050426 | 0.84 | AKT2 (0.55) | JAK3AKT2GSK3BKITJAK2 | |
| SCHEMBL1047861 | 0.80 | AKT1 (0.51) | JAK3AKT2GSK3BKITJAK2 | |
| SCHEMBL1083643 | 0.77 | AKT2 (0.53) | JAK3AKT2GSK3BKITJAK2 | |
| SCHEMBL16105927 | 0.77 | JAK2 (0.50) | JAK3AKT2GSK3BKITJAK2 | |
| SCHEMBL323629 | 0.76 | JAK3 (0.45) | JAK3AKT2GSK3BKITJAK2 | |
| SCHEMBL10317875 | 0.75 | JAK3 (0.47) | JAK3AKT2GSK3BKITJAK2 | |
| SCHEMBL1046403 | 0.75 | JAK3 (0.47) | JAK3AKT2GSK3BKITJAK2 | |
| SCHEMBL12958812 | 0.75 | JAK3 (0.47) | JAK3AKT2GSK3BKITJAK2 | |
| SCHEMBL1050064 | 0.74 | AKT2 (0.53) | JAK3AKT2GSK3BKITJAK2 | |
| SCHEMBL12958977 | 0.72 | AKT2 (0.55) | JAK3AKT2GSK3BKITJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451813-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | Leo Pharma A/S (DK) | 2012-05-16 | — | — | EP | claimed |
| WO-2011003418-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-01-13 | — | — | WO | claimed |
| EP-2451813-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | Leo Pharma A/S (DK) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011003418-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-01-13 | — | — | WO | disclosed |