Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 14/20 | 0.52 |
| ▸ | JAK3 | P52333 | 10/20 | 0.52 |
| ▸ | JAK1 | P23458 | 9/20 | 0.52 |
| ▸ | TYK2 | P29597 | 5/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1050426 | 0.86 | AKT2 (0.55) | AKT2ROCK2AKT1AKT3JAK2 | |
| SCHEMBL1047861 | 0.84 | AKT1 (0.51) | AKT2AKT1JAK2JAK3JAK1 | |
| SCHEMBL10321596 | 0.78 | JAK2 (0.54) | AKT2ROCK2AKT1AKT3JAK2 | |
| SCHEMBL1049384 | 0.78 | JAK2 (0.54) | AKT2ROCK2AKT1AKT3JAK2 | |
| SCHEMBL1049059 | 0.78 | ROCK2 (0.55) | AKT2ROCK2AKT1AKT3JAK2 | |
| SCHEMBL1046404 | 0.77 | JAK3 (0.44) | AKT2JAK2JAK3JAK1LCK | |
| SCHEMBL324757 | 0.77 | AKT1 (0.56) | AKT2ROCK2AKT1AKT3JAK2 | |
| SCHEMBL16105879 | 0.76 | JAK2 (0.53) | AKT2ROCK2AKT1AKT3JAK2 | |
| SCHEMBL10277208 | 0.76 | ROCK2 (0.53) | AKT2ROCK2AKT1AKT3JAK2 | |
| SCHEMBL16105927 | 0.75 | JAK2 (0.50) | AKT2JAK2JAK3JAK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451813-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | Leo Pharma A/S (DK) | 2012-05-16 | — | — | EP | claimed |
| WO-2011003418-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-01-13 | — | — | WO | claimed |
| EP-2451813-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | Leo Pharma A/S (DK) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011003418-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-01-13 | — | — | WO | disclosed |