Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.52 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10464304 | 1.00 | CYP19A1 (0.52) | CYP19A1TBXAS1PDE3BPDE3ACRBN | |
| SCHEMBL10464398 | 0.88 | TBXAS1 (0.48) | CYP19A1TBXAS1PDE3BPDE3ACRBN | |
| SCHEMBL10464397 | 0.88 | TBXAS1 (0.48) | CYP19A1TBXAS1PDE3BPDE3ACRBN | |
| SCHEMBL10461627 | 0.85 | TBXAS1 (0.53) | CYP19A1TBXAS1PDE3BPDE3ACRBN | |
| SCHEMBL10461629 | 0.85 | TBXAS1 (0.53) | CYP19A1TBXAS1PDE3BPDE3ACRBN | |
| SCHEMBL10462993 | 0.83 | TBXAS1 (0.52) | CYP19A1TBXAS1PDE3BPDE3ACRBN | |
| SCHEMBL10462991 | 0.83 | TBXAS1 (0.52) | CYP19A1TBXAS1PDE3BPDE3ACRBN | |
| SCHEMBL10463898 | 0.82 | TBXAS1 (0.54) | CYP19A1TBXAS1PDE3BPDE3ACRBN | |
| SCHEMBL10463897 | 0.82 | TBXAS1 (0.54) | CYP19A1TBXAS1PDE3BPDE3ACRBN | |
| SCHEMBL10464306 | 0.80 | CRBN (0.45) | CYP19A1TBXAS1PDE3BPDE3ACRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4921862-A | Carbostyril derivatives as combined thromboxane synthetase and cyclic-amp phosphodiesterase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1990-05-01 | — | — | US | disclosed |
| US-4792561-A | ANTICOAGULANTS, CARDIOVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1988-12-20 | — | — | US | disclosed |