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Sugi Predict / Targets / TBXAS1

TBXAS1

Thromboxane-A synthase · P24557 · TBXAS1 on Sugi Atlas →

147,063 patent compounds predicted against TBXAS1, 92,467 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
(E)-Isbogrel (E)-Isbogrel (SCHEMBL4060) 1.00 20/20
(E)-Isbogrel (E)-Isbogrel (SCHEMBL4061) 1.00 20/20
Terbogrel Terbogrel (SCHEMBL42849) 1.00 20/20
SCHEMBL149467 SCHEMBL149467 1.00 20/20
Imitrodast Imitrodast (SCHEMBL99497) 0.98 20/20
Terbogrel Terbogrel (SCHEMBL42848) 0.74 20/20
Dazoxiben Dazoxiben (SCHEMBL11554) 1.00 18/20
SCHEMBL47375 SCHEMBL47375 0.53 17/20
SCHEMBL47371 SCHEMBL47371 0.46 17/20
SCHEMBL47383 SCHEMBL47383 0.53 16/20
SCHEMBL47372 SCHEMBL47372 0.51 16/20
SCHEMBL46048 SCHEMBL46048 0.48 16/20
SCHEMBL45906 SCHEMBL45906 0.48 16/20
SCHEMBL76498 SCHEMBL76498 0.57 15/20
SCHEMBL45932 SCHEMBL45932 0.56 15/20
Ozagrel Ozagrel (SCHEMBL4210) 1.00 14/20
Ozagrel Ozagrel (SCHEMBL4211) 1.00 14/20
Ozagrel Ozagrel (SCHEMBL36182) 1.00 14/20
Ozagrel Ozagrel (SCHEMBL36183) 1.00 14/20
SCHEMBL126573 SCHEMBL126573 0.54 14/20

Clinical trials — most relevant to TBXAS1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study PHASE4COMPLETED
Thromboxane Function in Women With Endometriosis PHASE4RECRUITING
Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes PHASE4UNKNOWN
European Celecoxib Trial in Primary Breast Cancer PHASE3COMPLETED
Ramatroban/Montelukast Versus Montelukast/Placebo on the Early Allergic Reaction in Asthma Sensitive to House Dust Mite PHASE2/PHASE3WITHDRAWN
Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes PHASE3UNKNOWN
Lovaza's Effect on the Activation of Platelets PHASE2COMPLETED
Thromboxane Receptor Antagonist to Improve Endothelial Function PHASE2COMPLETED
Chemoprevention Trial - Anastrozole in Ductal Carcinoma In Situ (DCIS) in Postmenopausal Women PHASE2COMPLETED
Vitamin D Versus Sildenafil Citrate in Fetal Growth Restriction PHASE1COMPLETED
Aspirin Resistance in Systemic Lupus Erythematosus (SLE) PHASE1COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides PHASE1COMPLETED
Thrombin Regulated Platelet Activation nanCOMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
Identification of Genes and Pathogenesis Involved in Familial Thoracic Aortic Aneurysm nanCOMPLETED
StratosPHere (Non-interventional Study) nanCOMPLETED
Ischemia Care Biomarkers of Acute Stroke Etiology (BASE) nanCOMPLETED
Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B nanCOMPLETED
Lipidomics Screening of Anti-inflammatory Drugs and Drug Candidates in Vitro - Part A nanACTIVE_NOT_RECRUITING
Omega-3 Fatty Acids Supplementation and Atherothrombotic Biomarkers in Type 2 Diabetes and Cardiovascular Disease. nanCOMPLETED
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions nanRECRUITING
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Inflammation, Platelets and Sickle Cell Disease nanACTIVE_NOT_RECRUITING
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock nanCOMPLETED
Normal Donor Blood Draws for Platelet Studies and Biomarker Evaluation (ND-PLT) nanRECRUITING
Study of Constitutional Platelet Disease nanUNKNOWN
Biomarkers of Acute Stroke in Clinic nanUNKNOWN
Molecular Biology of Polycythemia and Thrombocytosis nanRECRUITING
Platelets Function and Cardiovascular Events in Patients With End Stage Renal Disease nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a TBXAS1 binder may also engage these)

ProteinNameSimilarity
Q2PG45 — 0.999 Q2PG45 →
Q2KIG5 — 0.998 Q2KIG5 →
P36423 — 0.997 P36423 →
P49430 — 0.996 P49430 →
P47787 — 0.993 P47787 →
P82713 — 0.991 P82713 →
Q9VRI9 — 0.988 Q9VRI9 →
Q9VVN6 — 0.988 Q9VVN6 →
Q27698 — 0.987 Q27698 →
Q9GQM9 — 0.987 Q9GQM9 →
Q9V675 — 0.987 Q9V675 →
Q9V676 — 0.987 Q9V676 →
Q9VYQ7 — 0.986 Q9VYQ7 →
Q9VWR2 — 0.986 Q9VWR2 →
P51870 — 0.986 P51870 →
Q9V9L1 — 0.985 Q9V9L1 →
Q9VRB3 — 0.985 Q9VRB3 →
Q9GLD2 — 0.984 Q9GLD2 →
CYP4F3 Cytochrome P450 4F3 0.984 landscape →
O42145 — 0.984 O42145 →
Q9V7G5 — 0.984 Q9V7G5 →
Q2XVA1 — 0.984 Q2XVA1 →
Q27515 — 0.983 Q27515 →
Q92087 — 0.983 Q92087 →
P51871 — 0.983 P51871 →
Q27518 — 0.982 Q27518 →
Q9V776 — 0.982 Q9V776 →
P51869 — 0.982 P51869 →
Q27513 — 0.982 Q27513 →
Q9V979 — 0.982 Q9V979 →