Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 2/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17596693 | 0.88 | SCD (0.41) | PDE5AKDM4EMEN1KMT2ASCD | |
| SCHEMBL2786872 | 0.85 | GAA (0.53) | PDE5AKDM4EMEN1KMT2ASCD | |
| SCHEMBL6584892 | 0.84 | SMN1; SMN2 (0.45) | PDE5AKDM4EMEN1KMT2ANPC1 | |
| SCHEMBL29530751 | 0.82 | CSNK2A1 (0.50) | PDE5AKDM4EMEN1KMT2ANPC1 | |
| SCHEMBL11091142 | 0.82 | PDE5A (0.46) | PDE5AKDM4EMEN1KMT2ANPC1 | |
| SCHEMBL10756603 | 0.82 | PDE5A (0.46) | PDE5AKDM4EMEN1KMT2ANPC1 | |
| SCHEMBL9813319 | 0.81 | NPC1 (0.41) | PDE5AKDM4EMEN1KMT2ANPC1 | |
| SCHEMBL10437870 | 0.81 | PDE5A (0.39) | PDE5AKDM4EMEN1KMT2ANPC1 | |
| SCHEMBL2786880 | 0.80 | TP53 (0.59) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27481508 | 0.79 | PDE5A (0.43) | PDE5AKDM4EMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933355-A | ALDOSE REDUCTASE INHIBITORS | SANKYO COMPANY LIMITED (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0337819-A1 | Thiazole derivatives, their preparation and their use in the treatment of diabetes complications | Sankyo Company Limited (JP) | 1989-10-18 | — | — | EP | disclosed |