Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL101951 | 0.79 | ALDH1A1 (0.41) | ALDH1A1KDM4EMAPTSMN1; SMN2TSHR | |
| SCHEMBL841946 | 0.78 | KDM4E (0.49) | ALDH1A1GAAKDM4EHSD17B10MAPT | |
| SCHEMBL102723 | 0.76 | KMT2A (0.46) | ALDH1A1GAAKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL17163996 | 0.76 | GAA (0.44) | ALDH1A1HPGDGAAKDM4EMAPT | |
| SCHEMBL106227 | 0.76 | KDM4E (0.38) | ALDH1A1GAAKDM4EHSD17B10MAPT | |
| SCHEMBL105205 | 0.76 | SMN1; SMN2 (0.38) | ALDH1A1GAAKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL9201767 | 0.72 | KDM4E (0.41) | ALDH1A1HPGDKDM4EHSD17B10MAPT | |
| SCHEMBL26690355 | 0.72 | ALDH1A1 (0.57) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13861497 | 0.71 | TSHR (0.42) | ALDH1A1HPGDGAAKDM4EHSD17B10 | |
| SCHEMBL1412412 | 0.69 | NPC1 (0.47) | ALDH1A1GAAKDM4ESMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426110-B1 | PYRAZOLYL ACRYLONITRILE COMPOUNDS AND USES THEREOF | SINOCHEM CORP (CN) | 2013-10-16 | — | — | EP | disclosed |
| EP-2426110-B1 | PYRAZOLYL ACRYLONITRILE COMPOUNDS AND USES THEREOF | SINOCHEM CORP (CN) | 2013-10-16 | — | — | EP | disclosed |
| US-8455532-B2 | Pyrazolyl acrylonitrile compounds and uses thereof | SHENYANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD. (CN) | 2013-06-04 | — | — | US | disclosed |
| US-8455532-B2 | Pyrazolyl acrylonitrile compounds and uses thereof | SHENYANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD. (CN) | 2013-06-04 | — | — | US | disclosed |
| US-8455532-B2 | Pyrazolyl acrylonitrile compounds and uses thereof | SHENYANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD. (CN) | 2013-06-04 | — | — | US | disclosed |
| EP-2426110-A1 | PYRAZOLYL ACRYLONITRILE COMPOUNDS AND USES THEREOF | Sinochem Corporation (CN) | 2012-03-07 | — | — | EP | disclosed |
| EP-2426110-A1 | PYRAZOLYL ACRYLONITRILE COMPOUNDS AND USES THEREOF | Sinochem Corporation (CN) | 2012-03-07 | — | — | EP | disclosed |
| US-20120035236-A1 | Pyrazolyl Acrylonitrile Compounds and Uses Thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2012-02-09 | — | — | US | disclosed |
| US-20120035236-A1 | Pyrazolyl Acrylonitrile Compounds and Uses Thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2012-02-09 | — | — | US | disclosed |
| US-20120035236-A1 | Pyrazolyl Acrylonitrile Compounds and Uses Thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035236-A1 | Pyrazolyl Acrylonitrile Compounds and Uses Thereof | CBR3, C3AR1, C5 | ALDH1A1 337/4885HPGD 2031/4885GAA 4389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.