Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10465398 | 1.00 | HPGD (0.63) | HPGDSMN1; SMN2GFERMAPTALDH1A1 | |
| SCHEMBL7318717 | 0.81 | HPGD (0.69) | HPGDSMN1; SMN2GFERMAPTALDH1A1 | |
| SCHEMBL11779617 | 0.81 | SMN1; SMN2 (0.69) | HPGDSMN1; SMN2GFERMAPTALDH1A1 | |
| SCHEMBL11779616 | 0.81 | SMN1; SMN2 (0.69) | HPGDSMN1; SMN2GFERMAPTALDH1A1 | |
| SCHEMBL7318722 | 0.81 | HPGD (0.69) | HPGDSMN1; SMN2GFERMAPTALDH1A1 | |
| SCHEMBL10465388 | 0.78 | HPGD (0.69) | HPGDSMN1; SMN2GFERMAPTALDH1A1 | |
| SCHEMBL10465389 | 0.78 | HPGD (0.69) | HPGDSMN1; SMN2GFERMAPTALDH1A1 | |
| SCHEMBL2359509 | 0.78 | ALDH1A1 (0.61) | HPGDSMN1; SMN2MAPTALDH1A1CYP3A4 | |
| SCHEMBL3649780 | 0.78 | HPGD (1.00) | HPGDSMN1; SMN2GFERMAPTALDH1A1 | |
| SCHEMBL3649775 | 0.78 | HPGD (1.00) | HPGDSMN1; SMN2GFERMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4895867-A | 2-(5-phenyl-2-furanyl)imidazoles useful as cardiotonic agents | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1990-01-23 | — | — | US | disclosed |
| EP-0251380-A2 | 2- (5-phenyl-2-furanyl) imidazoles useful as cardiotonic agents | Norwich Eaton Pharmaceuticals, Inc. (US) | 1988-01-07 | — | — | EP | disclosed |