Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 3/20 | 0.44 |
| ▸ | MMP9 | P14780 | 3/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16500666 | 0.82 | GAA (0.53) | HRH3HDAC8 | |
| SCHEMBL12065126 | 0.82 | GAA (0.53) | HRH3HDAC8 | |
| SCHEMBL10467641 | 0.82 | GAA (0.53) | HRH3HDAC8 | |
| SCHEMBL10467651 | 0.78 | CXCR4 (0.47) | TACR2 | |
| SCHEMBL10467652 | 0.78 | CXCR4 (0.47) | TACR2 | |
| SCHEMBL24608268 | 0.78 | HDAC8 (0.53) | HDAC8HDAC4HDAC1HDAC6 | |
| SCHEMBL13399687 | 0.78 | HDAC8 (0.53) | HDAC8HDAC4HDAC1HDAC6 | |
| SCHEMBL13399246 | 0.78 | HDAC8 (0.53) | HDAC8HDAC4HDAC1HDAC6 | |
| SCHEMBL13399551 | 0.78 | HDAC8 (0.53) | HDAC8HDAC4HDAC1HDAC6 | |
| SCHEMBL1146928 | 0.78 | HDAC8 (0.53) | HDAC8HDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4940709-A | PLATELET ACTIVATING FACTOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-07-10 | — | — | US | disclosed |
| EP-0181152-B1 | PIPERAZINE COMPOUND AS PAF-ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-09-13 | — | — | EP | disclosed |
| US-4806538-A | ANTICOAGULANT, HYPOTENSIVE AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-02-21 | — | — | US | disclosed |
| EP-0181152-A1 | Piperazine compound as PAF-antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-14 | — | — | EP | disclosed |