Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 6/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.57 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10466705 | 1.00 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL10465201 | 0.88 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL10466589 | 0.88 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8927548 | 0.87 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL10466707 | 0.86 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL8926448 | 0.86 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL10466276 | 0.85 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL10466195 | 0.85 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL10480281 | 0.85 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL10465249 | 0.83 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4959360-A | α-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-09-25 | — | — | US | claimed |
| WO-1989012050-A1 | alpha-ADRENERGIC RECEPTOR ANTAGONISTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-12-14 | — | — | WO | claimed |
| EP-0344980-A2 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1989-12-06 | — | — | EP | claimed |
| US-4959360-A | α-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-09-25 | — | — | US | disclosed |
| WO-1989012050-A1 | alpha-ADRENERGIC RECEPTOR ANTAGONISTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-12-14 | — | — | WO | disclosed |