Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | PPM1B | O75688 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.44 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PPP5C | P53041 | 1/20 | 0.44 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570299 | 0.82 | KDM4E (0.55) | SMN1; SMN2KDM4EGMNNPPM1BLMNA | |
| SCHEMBL722306 | 0.82 | KDM4E (0.55) | SMN1; SMN2KDM4EGMNNPPM1BLMNA | |
| SCHEMBL21338787 | 0.82 | KDM4E (0.55) | SMN1; SMN2KDM4EGMNNPPM1BLMNA | |
| SCHEMBL19576251 | 0.82 | KDM4E (0.55) | SMN1; SMN2KDM4EGMNNPPM1BLMNA | |
| SCHEMBL15498640 | 0.82 | KDM4E (0.55) | SMN1; SMN2KDM4EGMNNPPM1BLMNA | |
| SCHEMBL10080802 | 0.82 | KDM4E (0.55) | SMN1; SMN2KDM4EGMNNPPM1BLMNA | |
| SCHEMBL15498551 | 0.82 | KDM4E (0.55) | SMN1; SMN2KDM4EGMNNPPM1BLMNA | |
| SCHEMBL12172590 | 0.77 | KDM4E (0.50) | SMN1; SMN2KDM4EGMNNPPM1BLMNA | |
| SCHEMBL23139797 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM4EGMNNPPM1BLMNA | |
| SCHEMBL19057999 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM4EGMNNPPM1BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117362318-A | PB2 inhibitor and preparation method and application thereof | 西藏海思科制药有限公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-115698011-B | PB2 inhibitor and preparation method and application thereof | 四川海思科制药有限公司 | 2023-10-20 | — | — | CN | disclosed |
| EP-4180434-A1 | PB2 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Sichuan Haisco Pharmaceutical Co., Ltd. (CN) | 2023-05-17 | — | — | EP | disclosed |
| CN-115698011-A | PB2 inhibitor and preparation method and application thereof | 四川海思科制药有限公司 | 2023-02-03 | — | — | CN | disclosed |
| US-4892943-A | ANTIPSYCHOTIC, ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-01-09 | — | — | US | disclosed |