Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.81 |
| ▸ | PDE3B | Q13370 | 15/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 15/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 3/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10474361 | 0.88 | SMN1; SMN2 (0.75) | SMN1; SMN2MAPTPDE3BPDE3AKDM4E | |
| SCHEMBL10472264 | 0.85 | PDE3B (0.75) | SMN1; SMN2MAPTPDE3BPDE3AKDM4E | |
| SCHEMBL10472269 | 0.84 | SMN1; SMN2 (0.76) | SMN1; SMN2MAPTPDE3BPDE3AKDM4E | |
| SCHEMBL10472837 | 0.83 | MAPT (0.74) | SMN1; SMN2MAPTPDE3BPDE3AKDM4E | |
| SCHEMBL10472265 | 0.83 | MAPT (0.74) | SMN1; SMN2MAPTPDE3BPDE3AKDM4E | |
| SCHEMBL10475042 | 0.82 | PDE3B (0.67) | SMN1; SMN2MAPTPDE3BPDE3AKDM4E | |
| SCHEMBL11119840 | 0.80 | SMN1; SMN2 (0.74) | SMN1; SMN2MAPTPDE3BPDE3AKDM4E | |
| SCHEMBL3723998 | 0.79 | PDE3B (1.00) | SMN1; SMN2MAPTPDE3BPDE3AKDM4E | |
| SCHEMBL3723997 | 0.79 | PDE3B (1.00) | SMN1; SMN2MAPTPDE3BPDE3AKDM4E | |
| SCHEMBL11170712 | 0.79 | PDE3B (0.64) | SMN1; SMN2MAPTPDE3BPDE3AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4965263-A | HYPOTENSIVE AGENTS | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1990-10-23 | — | — | US | disclosed |
| EP-0107735-B1 | NOVEL PYRIDAZINONE DERIVATIVES | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1988-10-19 | — | — | EP | disclosed |
| US-4639451-A | HYPOTENSIVE AGENTS, ANTICOAGULANTS | MITSUI TOATSU KAGAKU-KABUSHIKI KAISHA (JP) | 1987-01-27 | — | — | US | disclosed |
| EP-0107735-A1 | NOVEL PYRIDAZINONE DERIVATIVES | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1984-05-09 | — | — | EP | disclosed |