SCHEMBL3723997

SCHEMBL3723997

CC(=O)Nc1ccc(C2=NNC(=O)C[C@H]2C)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 16/20 1.00
PDE3A Q14432 16/20 1.00
KDM4E B2RXH2 2/20 0.64
ALDH1A1 P00352 2/20 0.64
CYP1A2 P05177 1/20 0.64
CYP3A4 P08684 1/20 0.64
ALOX15 P16050 1/20 0.64
TSHR P16473 1/20 0.64
MAPK1 P28482 1/20 0.64
LMNA P02545 1/20 0.64
BLM P54132 1/20 0.64
NPSR1 Q6W5P4 1/20 0.64
SMN1; SMN2 Q16637 2/20 0.64
MAPT P10636 1/20 0.64
TNNC1 P63316 1/20 0.61
PDE4A P27815 2/20 0.54
PDE4B Q07343 2/20 0.54
PDE4C Q08493 2/20 0.54
PDE4D Q08499 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3723998 1.00 PDE3B (1.00) PDE3BPDE3AKDM4EALDH1A1CYP1A2
Methylamine SCHEMBL10474969 0.97 PDE3B (0.95) PDE3BPDE3AKDM4EALDH1A1CYP1A2
Dimethylamine SCHEMBL10475180 0.97 PDE3B (0.95) PDE3BPDE3AKDM4EALDH1A1CYP1A2
SCHEMBL5678932 0.88 PDE3B (0.77) PDE3BPDE3AKDM4EALDH1A1CYP1A2
SCHEMBL5678929 0.88 PDE3B (0.77) PDE3BPDE3AKDM4EALDH1A1CYP1A2
SCHEMBL11180354 0.87 PDE3B (0.77) PDE3BPDE3AKDM4EALDH1A1CYP1A2
SCHEMBL11165047 0.87 PDE3B (0.77) PDE3BPDE3AKDM4EALDH1A1CYP1A2
SCHEMBL11160996 0.87 PDE3B (0.78) PDE3BPDE3AKDM4EALDH1A1CYP1A2
SCHEMBL10472650 0.87 PDE3B (0.76) PDE3BPDE3AKDM4EALDH1A1CYP1A2
SCHEMBL10472264 0.86 PDE3B (0.75) PDE3BPDE3AKDM4EALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4076398-B1 LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HF-PEF) TENAX THERAPEUTICS INC (US) 2026-02-18 EP claimed
US-20250064799-A1 ORAL FORMULATIONS OF LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION TENAX THERAPEUTICS, INC. (US) 2025-02-27 US claimed
US-20250025460-A1 USE OF A COMBINATION OF LEVOSIMENDAN AND AN SGLT-2 INHIBITOR TO TREAT HEART FAILURE TENAX THERAPEUTICS, INC. (US) 2025-01-23 US claimed
EP-4456897-A1 ORAL FORMULATIONS OF LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION Tenax Therapeutics, Inc. (US) 2024-11-06 EP claimed
US-20240269134-A1 LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HFpEF) TENAX THERAPEUTICS, INC. (US) 2024-08-15 US claimed
US-11969424-B2 Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (PH-HFpEF) TENAX THERAPEUTICS, INC. (US) 2024-04-30 US claimed
US-11701355-B2 Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (PH-HFpEF) TENAX THERAPEUTICS, INC. (US) 2023-07-18 US claimed
WO-2023130028-A1 ORAL FORMULATIONS OF LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION TENAX THERAPEUTICS, INC. (US) 2023-07-06 WO claimed
US-20230107461-A1 LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HFpEF) TENAX THERAPEUTICS, INC. (US) 2023-04-06 US claimed
US-11607412-B2 Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (PH-HFpEF) TENAX THERAPEUTICS INC. (US) 2023-03-21 US claimed
US-20220370445-A1 METHODS FOR ADMINISTERING (R)-N-[4-(1,4,5,6-TETRAHYDRO-6-OXO-3-PYRIDAZINYL)PHENYL]ACETAMIDE ORION CORPORATION (FI) 2022-11-24 US claimed
EP-4076398-A1 LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HF-PEF) Tenax Therapeutics, Inc. (US) 2022-10-26 EP claimed
EP-3993773-A1 METHODS FOR ADMINISTERING (R)-N-[4-(1,4,5,6-TETRAHYDRO-6-OXO-3-PYRIDAZINYL)PHENYL]ACETAMIDE Orion Corporation (FI) 2022-05-11 EP claimed
US-20220096470-A1 PHARMACEUTICAL COMPOSITIONS FOR SUBCUTANEOUS ADMINISTRATION OF LEVOSIMENDAN TENAX THERAPEUTICS, INC. (US) 2022-03-31 US claimed
EP-1581227-B1 A METHOD FOR TREATING RENAL FAILURE ORION CORP (FI) 2007-02-28 EP claimed
US-20060166994-A1 Method for treating renal failure ORION CORPORATION (FI) 2006-07-27 US claimed
US-7045147-B1 Controlled release peroral compositions of levosimendan ORION CORPORATION (FI) 2006-05-16 US claimed
EP-1087769-B1 USE OF A PYRIDAZINONE DERIVATIVE AS CALCIUM SENSITIZER ORION CORP (FI) 2004-03-10 EP claimed
US-RE38102-E1 Use of a pyridazinone derivative ORION CORPORATION (FI) 2003-04-29 US claimed
US-12616694-B2 Pharmaceutical compositions for subcutaneous administration of levosimendan TENAX THERAPEUTICS, INC. (US) 2026-05-05 US disclosed
EP-4076398-B1 LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HF-PEF) TENAX THERAPEUTICS INC (US) 2026-02-18 EP disclosed
CN-119745787-A Transdermal gel preparation and preparation method thereof 浙江仙琚制药股份有限公司 2025-04-04 CN disclosed
US-20250064799-A1 ORAL FORMULATIONS OF LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION TENAX THERAPEUTICS, INC. (US) 2025-02-27 US disclosed
US-20250025460-A1 USE OF A COMBINATION OF LEVOSIMENDAN AND AN SGLT-2 INHIBITOR TO TREAT HEART FAILURE TENAX THERAPEUTICS, INC. (US) 2025-01-23 US disclosed
US-20250025460-A1 USE OF A COMBINATION OF LEVOSIMENDAN AND AN SGLT-2 INHIBITOR TO TREAT HEART FAILURE TENAX THERAPEUTICS, INC. (US) 2025-01-23 US disclosed
EP-4456897-A1 ORAL FORMULATIONS OF LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION Tenax Therapeutics, Inc. (US) 2024-11-06 EP disclosed
US-20240269134-A1 LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HFpEF) TENAX THERAPEUTICS, INC. (US) 2024-08-15 US disclosed
US-11969424-B2 Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (PH-HFpEF) TENAX THERAPEUTICS, INC. (US) 2024-04-30 US disclosed
US-11701355-B2 Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (PH-HFpEF) TENAX THERAPEUTICS, INC. (US) 2023-07-18 US disclosed
WO-2023130028-A1 ORAL FORMULATIONS OF LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION TENAX THERAPEUTICS, INC. (US) 2023-07-06 WO disclosed
US-20230107461-A1 LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HFpEF) TENAX THERAPEUTICS, INC. (US) 2023-04-06 US disclosed
US-11607412-B2 Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (PH-HFpEF) TENAX THERAPEUTICS INC. (US) 2023-03-21 US disclosed
US-20220370445-A1 METHODS FOR ADMINISTERING (R)-N-[4-(1,4,5,6-TETRAHYDRO-6-OXO-3-PYRIDAZINYL)PHENYL]ACETAMIDE ORION CORPORATION (FI) 2022-11-24 US disclosed
US-20220370445-A1 METHODS FOR ADMINISTERING (R)-N-[4-(1,4,5,6-TETRAHYDRO-6-OXO-3-PYRIDAZINYL)PHENYL]ACETAMIDE ORION CORPORATION (FI) 2022-11-24 US disclosed
EP-4076398-A1 LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HF-PEF) Tenax Therapeutics, Inc. (US) 2022-10-26 EP disclosed
EP-3993773-A1 METHODS FOR ADMINISTERING (R)-N-[4-(1,4,5,6-TETRAHYDRO-6-OXO-3-PYRIDAZINYL)PHENYL]ACETAMIDE Orion Corporation (FI) 2022-05-11 EP disclosed
US-20220096470-A1 PHARMACEUTICAL COMPOSITIONS FOR SUBCUTANEOUS ADMINISTRATION OF LEVOSIMENDAN TENAX THERAPEUTICS, INC. (US) 2022-03-31 US disclosed
US-20220071995-A1 COMPOSITIONS AND METHODS FOR CANCER EXPRESSING PDE3A OR SLFN12 THE BROAD INSTITUTE, INC. (US) 2022-03-10 US disclosed
US-11213524-B2 Pharmaceutical compositions for subcutaneous administration of levosimendan TENAX THERAPEUTICS, INC. (US) 2022-01-04 US disclosed
US-11207320-B2 Compositions and methods for cancer expressing PDE3A or SLFN12 THE BROAD INSTITUTE, INC. (US) 2021-12-28 US disclosed
US-20210393625-A1 LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HFpEF) TENAX THERAPEUTICS, INC. (US) 2021-12-23 US disclosed
EP-3411037-B1 COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER PATIENT STRATIFICATION AND CANCER TREATMENT Bayer Pharma AG (DE) 2021-10-20 EP disclosed
US-20210236504-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER PATIENT STRATIFICATION AND CANCER TREATMENT BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2021-08-05 US disclosed
US-20210177840-A1 LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HFpEF) TENAX THERAPEUTICS, INC. (US) 2021-06-17 US disclosed
US-10966986-B2 Compounds, compositions and methods for cancer patient stratification and cancer treatment BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2021-04-06 US disclosed
WO-2021001601-A1 METHODS FOR ADMINISTERING (R)-N-[4-(1,4,5,6-TETRAHYDRO-6-OXO-3-PYRIDAZINYL)PHENYL]ACETAMIDE ORION CORPORATION (FI) 2021-01-07 WO disclosed
WO-2021001601-A1 METHODS FOR ADMINISTERING (R)-N-[4-(1,4,5,6-TETRAHYDRO-6-OXO-3-PYRIDAZINYL)PHENYL]ACETAMIDE ORION CORPORATION (FI) 2021-01-07 WO disclosed
US-20200330463-A1 Pharmaceutical Compositions for Subcutaneous Administration of Levosimendan TENAX THERAPEUTICS, INC. (US) 2020-10-22 US disclosed
EP-2970145-B1 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER BROAD INST INC (US) 2020-05-06 EP disclosed
US-9890127-B2 Compounds and compositions for the treatment of cancer THE BROAD INSTITUTE, INC. (US) 2018-02-13 US disclosed
US-9890127-B2 Compounds and compositions for the treatment of cancer THE BROAD INSTITUTE, INC. (US) 2018-02-13 US disclosed
EP-3206690-A1 LEVOSIMENDAN FOR USE IN THE TREATMENT OF MOTOR NEURON DISEASES (E.G. ALS) Orion Corporation (FI) 2017-08-23 EP disclosed
WO-2017134231-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER PATIENT STRATIFICATION AND CANCER TREATMENT BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-08-10 WO disclosed
WO-2017027854-A1 COMPOSITIONS AND METHODS FOR CANCER EXPRESSING PDE3A OR SLFN12 THE BROAD INSTITUTE, INC. (US) 2017-02-16 WO disclosed
WO-2016059287-A1 LEVOSIMENDAN FOR USE IN THE TREATMENT OF MOTOR NEURON DISEASES (E.G. ALS) ORION CORPORATION (FI) 2016-04-21 WO disclosed
US-20160016913-A1 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER THE BROAD INSTITUTE, INC. (US) 2016-01-21 US disclosed
US-20160016913-A1 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER THE BROAD INSTITUTE, INC. (US) 2016-01-21 US disclosed
WO-2014164704-A2 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER THE BROAD INSTITUTE, INC. (US) 2014-10-09 WO disclosed
EP-2185141-A1 A COMBINATION TREATMENT ORION CORPORATION (FI) 2010-05-19 EP disclosed
WO-2009027577-A1 A COMBINATION TREATMENT ORION CORPORATION (FI) 2009-03-05 WO disclosed
WO-2008134602-A1 LEVOSIMENDAN DOSAGE REGIMEN ABBOTT LABORATORIES (US) 2008-11-06 WO disclosed
US-20080077025-A1 METHODS FOR DETERMINING HOW TO TREAT CONGESTIVE HEART FAILURE ABBOTT LABORATORIES 2008-03-27 US disclosed
US-20080070917-A1 METHODS FOR ADMINISTERING LEVOSIMENDAN ABBOTT LABORATORIES 2008-03-20 US disclosed
EP-1858518-A1 A COMBINATION TREATMENT FOR ENHANCING DIURESIS ORION CORPORATION (FI) 2007-11-28 EP disclosed
EP-1848434-A2 A METHOD FOR TREATING HEART FAILURE ORION CORPORATION (FI) 2007-10-31 EP disclosed
US-20070032557-A1 Method for administering levosimendan KIVIKKO MATTI 2007-02-08 US disclosed
WO-2007008907-A2 METHODS FOR DETERMINING HOW TO TREAT CONGESTIVE HEART FAILURE ABBOTT LABORATORIES (US) 2007-01-18 WO disclosed
US-20070010518-A1 Method for administering levosimendan ORION CORPORATION (FI) 2007-01-11 US disclosed
EP-1401450-B1 USE OF A PYRIDAZINONE DERIVATIVE FOR THE TREATMENT OF CONGESTIVE HEART FAILURE ORION CORP (FI) 2007-01-03 EP disclosed
WO-2006097570-A1 A COMBINATION TREATMENT FOR ENHANCING DIURESIS ORION CORPORATION (FI) 2006-09-21 WO disclosed
WO-2006087420-A2 A METHOD FOR TREATING HEART FAILURE ORION CORPORATION (FI) 2006-08-24 WO disclosed
WO-2006087419-A2 A METHOD FOR ADMINISTERING LEVOSIMENDAN ORION CORPORATION (FI) 2006-08-24 WO disclosed
EP-1581227-A1 A METHOD FOR TREATING RENAL FAILURE ORION CORPORATION (FI) 2005-10-05 EP disclosed
US-20040180895-A1 Use of a pyridazinone derivative ORION CORPORATION (FI) 2004-09-16 US disclosed
WO-2004060375-A1 A METHOD FOR TREATING RENAL FAILURE ORION CORPORATION (FI) 2004-07-22 WO disclosed
EP-1401450-A1 NEW USE OF A PYRIDAZINONE DERIVATIVE ORION CORPORATION (FI) 2004-03-31 EP disclosed
EP-1087769-B1 USE OF A PYRIDAZINONE DERIVATIVE AS CALCIUM SENSITIZER ORION CORP (FI) 2004-03-10 EP disclosed
US-RE38102-E1 Use of a pyridazinone derivative ORION CORPORATION (FI) 2003-04-29 US disclosed
US-RE38102-E1 Use of a pyridazinone derivative ORION CORPORATION (FI) 2003-04-29 US disclosed
WO-2003004035-A1 NEW USE OF A PYRIDAZINONE DERIVATIVE ORION CORPORATION (FI) 2003-01-16 WO disclosed
EP-1087769-A1 USE OF A PYRIDAZINONE DERATIVE ORION CORPORATION (FI) 2001-04-04 EP disclosed
WO-1999066932-A1 NEW USE OF A PYRIDAZINONE DERIVATIVE ORION CORPORATION (FI) 1999-12-29 WO disclosed
WO-1999056134-A1 A METHOD FOR MONITORING THE TOLERABILITY OF LEVOSIMENDAN ADMINISTRATION ORION CORPORATION (FI) 1999-11-04 WO disclosed
US-5905078-A TREATMENT OF NEUROHORMONAL IMBALANCE ORION CORPORATION (FI) 1999-05-18 US disclosed
US-5905078-A TREATMENT OF NEUROHORMONAL IMBALANCE ORION CORPORATION (FI) 1999-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200330463-A1 Pharmaceutical Compositions for Subcutaneous Administration of Levosimendan TNNC1, CS, MEF2D PDE3B 222/4885PDE3A 319/4885KDM4E 1585/4885
US-20210236504-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER PATIENT STRATIFICATION AND CANCER TREATMENT CREB1, CREBBP, SLFN12 PDE3B 11/4885PDE3A 7/4885KDM4E 2202/4885
US-20220370445-A1 METHODS FOR ADMINISTERING (R)-N-[4-(1,4,5,6-TETRAHYDRO-6-OXO-3-PYRIDAZINYL)PHENYL]ACETAMIDE CHRM5, KCNN4, TNNI3 PDE3B 447/4885PDE3A 374/4885KDM4E 2320/4885
US-10966986-B2 Compounds, compositions and methods for cancer patient stratification and cancer treatment SLFN12, CREB1, CREBBP PDE3B 10/4885PDE3A 6/4885KDM4E 2614/4885
US-20220071995-A1 COMPOSITIONS AND METHODS FOR CANCER EXPRESSING PDE3A OR SLFN12 SMPD3, SMPD1, SMPD2 PDE3B 21/4885PDE3A 15/4885KDM4E 2875/4885
US-11213524-B2 Pharmaceutical compositions for subcutaneous administration of levosimendan TNNC1, CS, MEF2D PDE3B 222/4885PDE3A 319/4885KDM4E 1585/4885
US-20160016913-A1 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER TP53, RB1, CDK4 PDE3B 2667/4885PDE3A 2661/4885KDM4E 1947/4885
US-20060166994-A1 Method for treating renal failure TNNI3, ATP6V1B1, REN PDE3B 65/4885PDE3A 66/4885KDM4E 3522/4885
US-12616694-B2 Pharmaceutical compositions for subcutaneous administration of levosimendan MEF2D, TNNC1, CFD PDE3B 130/4885PDE3A 287/4885KDM4E 1352/4885
US-20220096470-A1 PHARMACEUTICAL COMPOSITIONS FOR SUBCUTANEOUS ADMINISTRATION OF LEVOSIMENDAN TNNC1, CS, MEF2D PDE3B 222/4885PDE3A 319/4885KDM4E 1585/4885
US-11207320-B2 Compositions and methods for cancer expressing PDE3A or SLFN12 SMPD3, SMPD1, SMPD2 PDE3B 21/4885PDE3A 15/4885KDM4E 2875/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.