Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10474997 | 1.00 | CHRNB4 (0.36) | CHRNB4CHRNA3PDE4APDE4BPDE4C | |
| SCHEMBL10474619 | 1.00 | CHRNB4 (0.36) | CHRNB4CHRNA3PDE4APDE4BPDE4C | |
| SCHEMBL10473370 | 1.00 | CHRNB4 (0.36) | CHRNB4CHRNA3PDE4APDE4BPDE4C | |
| SCHEMBL10474431 | 1.00 | CHRNB4 (0.36) | CHRNB4CHRNA3PDE4APDE4BPDE4C | |
| SCHEMBL10474260 | 0.97 | FKBP1A (0.35) | CHRNB4CHRNA3PDE4APDE4BPDE4C | |
| SCHEMBL10473753 | 0.97 | FKBP1A (0.35) | CHRNB4CHRNA3PDE4APDE4BPDE4C | |
| SCHEMBL10474785 | 0.97 | FKBP1A (0.35) | CHRNB4CHRNA3PDE4APDE4BPDE4C | |
| SCHEMBL10472452 | 0.97 | FKBP1A (0.35) | CHRNB4CHRNA3PDE4APDE4BPDE4C | |
| SCHEMBL10474411 | 0.97 | FKBP1A (0.35) | CHRNB4CHRNA3PDE4APDE4BPDE4C | |
| SCHEMBL10473726 | 0.92 | S1PR1 (0.37) | ACECACNA2D1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920221-A | CENTRAL NERVOUS SYSTEM ACTIVE AGENTS | PFIZER INC. (US) | 1990-04-24 | — | — | US | disclosed |
| US-4576964-A | ANALGESICS, ANTIEMETICS | PFIZER INC. (US) | 1986-03-18 | — | — | US | disclosed |
| US-4476131-A | ANTIEMETICS, ANALGESICS | PFIZER INC. (US) | 1984-10-09 | — | — | US | disclosed |
| US-4473704-A | ANALGESICS, ANTIEMETICS | PFIZER INC. (US) | 1984-09-25 | — | — | US | disclosed |