Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 16/20 | 0.72 |
| ▸ | PDE3A | Q14432 | 16/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 3/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.51 |
| ▸ | GALR3 | O60755 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312486 | 0.91 | PDE3B (0.72) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11189228 | 0.91 | PDE3B (0.72) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10993762 | 0.90 | PDE3B (0.75) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10726763 | 0.89 | PDE3B (0.70) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11188424 | 0.89 | PDE3B (0.70) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11182623 | 0.89 | PDE3B (0.70) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11185074 | 0.88 | PDE3B (0.75) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11193378 | 0.87 | PDE3B (0.67) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10425081 | 0.87 | PDE3B (0.67) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11196413 | 0.87 | PDE3B (0.73) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4965263-A | HYPOTENSIVE AGENTS | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1990-10-23 | — | — | US | disclosed |
| EP-0107735-B1 | NOVEL PYRIDAZINONE DERIVATIVES | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1988-10-19 | — | — | EP | disclosed |
| US-4639451-A | HYPOTENSIVE AGENTS, ANTICOAGULANTS | MITSUI TOATSU KAGAKU-KABUSHIKI KAISHA (JP) | 1987-01-27 | — | — | US | disclosed |
| EP-0107735-A1 | NOVEL PYRIDAZINONE DERIVATIVES | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1984-05-09 | — | — | EP | disclosed |