Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 17/20 | 0.73 |
| ▸ | PDE3A | Q14432 | 17/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 4/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11189228 | 0.92 | PDE3B (0.72) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL7312486 | 0.92 | PDE3B (0.72) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10993762 | 0.89 | PDE3B (0.75) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11185074 | 0.89 | PDE3B (0.75) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11180354 | 0.88 | PDE3B (0.77) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11338882 | 0.88 | PDE3B (0.73) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10808986 | 0.88 | PDE3B (0.73) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11500958 | 0.87 | PDE3B (0.69) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10474968 | 0.87 | PDE3B (0.72) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10474439 | 0.87 | PDE3B (0.72) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4376771-A | ANTI-HYPERTENSIVE AGENTS AND ANTI-THROMBOTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 1983-03-15 | — | — | US | disclosed |
| EP-0000113-B1 | DIHYDROPYRIDAZONES, THEIR PREPARATION AND MEDICINES CONTAINING THEM AND DIHYDROPYRIDAZONES FOR USE IN MEDICAL TREATMENTS | BASF Aktiengesellschaft (DE) | 1981-09-16 | — | — | EP | disclosed |
| EP-0000113-A1 | Dihydropyridazones, their preparation and medicines containing them and dihydropyridazones for use in medical treatments | BASF Aktiengesellschaft (DE) | 1979-01-10 | — | — | EP | disclosed |