Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 11/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.72 |
| ▸ | TTR | P02766 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.72 |
| ▸ | PPARG | P37231 | 1/20 | 0.72 |
| ▸ | HTR2B | P41595 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.72 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.72 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391385 | 0.90 | PPARA (0.69) | PPARACYP2C9TSHRCYP2C8TTR | |
| SCHEMBL10473984 | 0.89 | PPARA (0.68) | PPARACYP2C9TSHRCYP2C8TTR | |
| SCHEMBL10641653 | 0.87 | PPARA (0.65) | PPARACYP2C9TSHRCYP2C8TTR | |
| SCHEMBL10474998 | 0.87 | NR1H4 (0.70) | PPARACYP2C9TSHRCYP2C8TTR | |
| SCHEMBL10641221 | 0.85 | PPARA (0.62) | PPARACYP2C9TSHRCYP2C8TTR | |
| Gemfibrozil SCHEMBL29398115 | 0.85 | PPARA (1.00) | PPARACYP2C9TSHRCYP2C8TTR | |
| Gemfibrozil SCHEMBL20770039 | 0.85 | PPARA (1.00) | PPARACYP2C9TSHRCYP2C8TTR | |
| Gemfibrozil SCHEMBL1880616 | 0.85 | PPARA (1.00) | PPARACYP2C9TSHRCYP2C8TTR | |
| Gemfibrozil SCHEMBL4813 | 0.85 | PPARA (1.00) | PPARACYP2C9TSHRCYP2C8TTR | |
| SCHEMBL21389589 | 0.85 | MEN1 (0.67) | PPARACYP2C9TSHRCYP2C8TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4975456-A | For inhibiting intestinal absorption of cholesterol and increasing high density lipoprotein | WARNER-LAMBERT COMPANY (US) | 1990-12-04 | — | — | US | disclosed |
| US-4882357-A | ANTICHOLESTEROL AGENT; INCREASES HIGH DENSITY LIPOPROTEINS | WARNER-LAMBERT COMPANY (US) | 1989-11-21 | — | — | US | disclosed |