Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gemfibrozil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 9/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | CYP2C8 | P10632 | 2/20 | 1.00 |
| ▸ | TTR | P02766 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | PPARG | P37231 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 1.00 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.59 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.57 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gemfibrozil SCHEMBL1880616 | 1.00 | PPARA (1.00) | PPARATSHRCYP2C9CYP2C8TTR | |
| Gemfibrozil SCHEMBL29398115 | 1.00 | PPARA (1.00) | PPARATSHRCYP2C9CYP2C8TTR | |
| Gemfibrozil SCHEMBL20770039 | 1.00 | PPARA (1.00) | PPARATSHRCYP2C9CYP2C8TTR | |
| Gemfibrozil SCHEMBL457931 | 0.99 | PPARA (0.97) | PPARATSHRCYP2C9CYP2C8TTR | |
| Gemfibrozil SCHEMBL21052128 | 0.99 | PPARA (0.97) | PPARATSHRCYP2C9CYP2C8TTR | |
| Gemfibrozil SCHEMBL10542601 | 0.99 | PPARA (0.97) | PPARATSHRCYP2C9CYP2C8TTR | |
| Gemfibrozil SCHEMBL6033508 | 0.95 | PPARA (0.90) | PPARATSHRCYP2C9CYP2C8TTR | |
| SCHEMBL21992001 | 0.93 | PPARA (0.86) | PPARATSHRCYP2C9CYP2C8TTR | |
| SCHEMBL30504804 | 0.88 | PPARA (0.79) | PPARATSHRCYP2C9CYP2C8TTR | |
| SCHEMBL9481043 | 0.88 | PPARA (0.79) | PPARATSHRCYP2C9CYP2C8TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 38269 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-122059900-A | Preparation method of high-optical-purity pematite | 山东科新药业有限公司 | 2026-05-19 | — | — | CN | claimed |
| WO-2026087680-A1 | TREATMENT FOR CARDIOVASCULAR DISEASE | SAPREME TECHNOLOGIES B.V. (NL) | 2026-04-30 | — | — | WO | claimed |
| US-20260108482-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS INC (US) | 2026-04-23 | — | — | US | claimed |
| US-12605354-B2 | Azelaic acid esters in the treatment or prevention of dyslipidemia and associated conditions | NEW FRONTIER LABS, LLC (US) | 2026-04-21 | — | — | US | claimed |
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| EP-4725479-A1 | PPAR AGONISTS FOR TREATMENT OF DISEASES ASSOCIATED WITH AATD | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2026-04-15 | — | — | EP | claimed |
| US-12582626-B2 | Methods and compositions for treating cancer | The Wister Institute of Anatomy and Biology (US) | 2026-03-24 | — | — | US | claimed |
| EP-4696381-A2 | MEDICINE | KOWA COMPANY, LTD. (JP) | 2026-02-18 | — | — | EP | claimed |
| EP-4691556-A2 | HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF | H. Lundbeck A/S (DK) | 2026-02-11 | — | — | EP | claimed |
| EP-0276807-A2 | Lipid regulating compositions | WARNER-LAMBERT COMPANY (US) | 1988-08-03 | — | — | EP | claimed |
| WO-1988005296-A2 | LPID REGULATING COMPOSITIONS | WARNER-LAMBERT COMPANY (US) | 1988-07-28 | — | — | WO | claimed |
| US-4753800-A | DRUGS ADSORBED ONTO MAGNESIUM ALUMINUM STEARATE | WARNER-LAMBERT COMPANY (US) | 1988-06-28 | — | — | US | claimed |
| CN-86108429-A | Confection or active material induction system | — | 1988-01-20 | — | — | CN | claimed |
| EP-0227603-A2 | Confectionery delivery system for actives | WARNER-LAMBERT COMPANY (US) | 1987-07-01 | — | — | EP | claimed |
| EP-0226161-A1 | Improved process for preparing 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid | WARNER-LAMBERT COMPANY (US) | 1987-06-24 | — | — | EP | claimed |
| US-4665226-A | Process for preparing 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid | WARNER-LAMBERT COMPANY (US) | 1987-05-12 | — | — | US | claimed |
| EP-0219458-A2 | Medicament adsorbates and their preparation | WARNER-LAMBERT COMPANY (US) | 1987-04-22 | — | — | EP | claimed |
| US-4250191-A | ADMINISTERING A PHENOXYACETIC ACID DERIVATIVE | EDWARDS K DAVID | 1981-02-10 | — | — | US | claimed |
| US-4126637-A | PROCESS FOR THE PRODUCTION OF 2,2-DIMETHYL-5-(2,5-XYLYLOXY)VALERIC ACID | WARNER-LAMBERT COMPANY (US) | 1978-11-21 | — | — | US | claimed |