Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.51 |
| ▸ | PDE4A | P27815 | 4/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10475273 | 0.93 | PDE3B (0.51) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10474223 | 0.91 | PDE3B (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10475459 | 0.88 | PDE3B (0.55) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10474317 | 0.87 | PDE3B (0.53) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10475454 | 0.86 | PDE3B (0.53) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10431227 | 0.86 | SMN1; SMN2 (0.57) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10475279 | 0.85 | PDE3B (0.52) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10475456 | 0.84 | PDE3B (0.54) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10431212 | 0.82 | BCHE (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9836412 | 0.79 | ALDH1A1 (0.51) | LMNAALDH1A1L3MBTL1GAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4914093-A | CARDIOVASCULAR DISORDERS | SANKYO COMPANY LIMITED (JP) | 1990-04-03 | — | — | US | claimed |
| EP-0178189-A2 | Pyridazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1986-04-16 | — | — | EP | claimed |