Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.41 |
| ▸ | HTR2C known ✓ | P28335 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 4/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL10476236 | 0.89 | HTR2A (0.38) | HTR2AHTR2CHTR2BFFAR1WDR5 | |
| Succinic Acid SCHEMBL10476159 | 0.89 | HTR2A (0.40) | HTR2AHTR2CHTR2BWDR5PDE5A | |
| Succinic Acid SCHEMBL506304 | 0.88 | FFAR1 (0.44) | HTR2AHTR2CHTR2BFFAR1HDAC1 | |
| Succinic Acid SCHEMBL10476256 | 0.87 | KMT2A (0.41) | HTR2AHTR2CHTR2BFFAR1WDR5 | |
| Succinic Acid SCHEMBL506605 | 0.86 | PPARG (0.45) | WDR5HDAC1HDAC6 | |
| Succinic Acid SCHEMBL10476120 | 0.85 | PDE5A (0.48) | HTR2AHTR2CHTR2BFFAR1WDR5 | |
| Succinic Acid SCHEMBL507210 | 0.85 | FFAR1 (0.47) | HTR2AHTR2CHTR2BFFAR1 | |
| Succinic Acid SCHEMBL507759 | 0.85 | PTGER2 (0.42) | HTR2AHTR2CHTR2BWDR5PTGER2 | |
| Succinic Acid SCHEMBL508091 | 0.84 | WDR5 (0.39) | HTR2AHTR2CHTR2BFFAR1WDR5 | |
| Hydrochloric Acid SCHEMBL10476239 | 0.84 | HTR2C (0.48) | HTR2AHTR2CHTR2BWDR5PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720836-B1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | disclosed |
| EP-2479168-A1 | 6-Substituted 2,3,4,5-Tetrahydro-1H-Benzo [d]Azepines as 5-HT2C Receptor Agonists | ELI LILLY AND COMPANY (US) | 2012-07-25 | — | — | EP | disclosed |