Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.37 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 13/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1048032 | 0.77 | JAK3 (0.48) | JAK3JAK2JAK1LCKTYK2 | |
| SCHEMBL1047706 | 0.76 | AKT2 (0.46) | HRH4AKT1KITAKT2JAK3 | |
| SCHEMBL1051297 | 0.75 | AKT1 (0.47) | AKT1 | |
| SCHEMBL1051265 | 0.75 | AKT1 (0.45) | AKT1 | |
| SCHEMBL323926 | 0.73 | AKT1 (0.55) | AKT1KITAKT2JAK3JAK2 | |
| SCHEMBL1049059 | 0.73 | ROCK2 (0.55) | AKT1AKT2JAK3JAK2JAK1 | |
| SCHEMBL323133 | 0.73 | JAK3 (0.52) | AKT1AKT2JAK3JAK2JAK1 | |
| SCHEMBL323632 | 0.71 | JAK3 (0.52) | AKT1AKT2JAK3LCK | |
| SCHEMBL1046963 | 0.70 | ROCK2 (0.53) | AKT1AKT2JAK3JAK2JAK1 | |
| SCHEMBL1049229 | 0.68 | JAK3 (0.62) | HRH4JAK3JAK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451813-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | Leo Pharma A/S (DK) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011003418-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-01-13 | — | — | WO | disclosed |