Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 8/20 | 0.73 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.73 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5994733 | 0.84 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL7137773 | 0.83 | CHRNB2 (0.96) | CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3 | |
| SCHEMBL11705873 | 0.78 | CHRNB2 (0.59) | CHRNB2CHRNA4KDM1A | |
| SCHEMBL32674546 | 0.76 | CHRNB2 (0.66) | CHRNB2CHRNA4KDM1A | |
| SCHEMBL11699947 | 0.75 | CHRNB2 (0.56) | CHRNB2CHRNA4HTR2C | |
| SCHEMBL6545918 | 0.75 | CHRNB2 (0.56) | CHRNB2CHRNA4HTR2C | |
| SCHEMBL11538560 | 0.74 | CHRNB4 (0.72) | CHRNB2CHRNA4CHRNB4CHRNA3HTR2C | |
| SCHEMBL11703659 | 0.74 | CHRNB2 (0.54) | CHRNB2CHRNA4HTR2C | |
| SCHEMBL11703811 | 0.74 | CHRNB2 (0.54) | CHRNB2CHRNA4HTR2C | |
| Hydrochloric Acid SCHEMBL11543466 | 0.73 | CHRNB4 (0.69) | CHRNB2CHRNA4CHRNB4CHRNA3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1020103-C | 2,3,4,5,6,7-hexahydro-2,7-methylene-1,5-benzoxazonin and 1,4-benzoxazonin | MADAUS & CO DR (DE) | 1993-03-17 | — | — | CN | disclosed |
| US-4859664-A | Derivatives of 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonines and -1,4-benzoxazonines, processes for their production and their use as pharmaceuticals | MADAUS GMBH & COMPANY (DE) | 1989-08-22 | — | — | US | disclosed |
| CN-87106267-A | 2, 3, 4, 5, 6, 7-hexahydro-2, 7-methano-1, 5-benzoxazonin and-1, 4-benzoxazonin, process for their preparation and pharmaceutical compositions containing them | — | 1988-04-13 | — | — | CN | disclosed |
| US-4082744-A | CNS, ANALGESICS, ANTITUSSIVE, SEDATIVES | NIHON IYAKUHIN KOGYO CO., LTD. (JA) | 1978-04-04 | — | — | US | disclosed |
| US-4008219-A | CNS ANALGESIC, ANTITUSSIVE, SEDATIVE | NIHON IYAKUHIN KOGYO CO., LTD. (JA) | 1977-02-15 | — | — | US | disclosed |