Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.48 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 3/20 | 0.35 |
| ▸ | NQO2 | P16083 | 3/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502223 | 0.92 | TOP2A (0.46) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL10503144 | 0.86 | TOP2A (0.39) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL10502264 | 0.85 | POLB (0.46) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL10502825 | 0.84 | TOP2A (0.46) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL10501981 | 0.84 | TOP2A (0.47) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL10921777 | 0.81 | TOP2A (0.34) | TOP2ATOP2B | |
| SCHEMBL10502841 | 0.80 | TOP2A (0.42) | TOP2ATOP2BESR1 | |
| SCHEMBL7494000 | 0.80 | TOP2A (0.68) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL10502412 | 0.78 | TOP2A (0.45) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL10477218 | 0.78 | TOP2A (0.58) | TOP2ATOP2BPOLBNPC1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0172632-B1 | Benzopyrano[4,3,2-cd]indazole compounds, processes for their production and pharmaceutical compositions comprising the compounds | WARNER-LAMBERT COMPANY (US) | 1989-08-30 | — | — | EP | disclosed |
| US-4806654-A | Processes for the preparation of benzo(chalcogeno)(4,3,2-cd)indazoles and intermediates thereof | WARNER-LAMBERT COMPANY (US) | 1989-02-21 | — | — | US | disclosed |
| US-4604390-A | FUNGICIDES, ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0172632-A1 | Benzopyrano[4,3,2-cd]indazole compounds, processes for their production and pharmaceutical compositions comprising the compounds | WARNER-LAMBERT COMPANY (US) | 1986-02-26 | — | — | EP | disclosed |