Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.39 |
| ▸ | NQO1 | P15559 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10477225 | 0.86 | TOP2A (0.48) | TOP2ATOP2BNPC1MITFPOLB | |
| SCHEMBL10502372 | 0.86 | EGFR (0.36) | TOP2ATOP2BNQO1EGFRNPC1 | |
| SCHEMBL10502272 | 0.84 | NQO1 (0.52) | TOP2ATOP2BNQO1EGFRNPC1 | |
| SCHEMBL10502264 | 0.84 | POLB (0.46) | TOP2ATOP2BNPC1MITFPOLB | |
| SCHEMBL10503145 | 0.83 | MCHR1 (0.37) | NQO1POLBRAD52KMT2AALDH1A1 | |
| SCHEMBL11747864 | 0.82 | TOP2A (0.39) | TOP2ATOP2BNQO1EGFRNPC1 | |
| SCHEMBL10502223 | 0.80 | TOP2A (0.46) | TOP2ATOP2BNPC1MITFPOLB | |
| SCHEMBL7492583 | 0.80 | TOP2A (0.56) | TOP2ATOP2BNQO1EGFRNPC1 | |
| Hydrochloric Acid SCHEMBL10477216 | 0.80 | TOP2A (0.55) | TOP2ATOP2BNQO1EGFRNPC1 | |
| SCHEMBL10477217 | 0.78 | TOP2A (0.49) | TOP2ATOP2BNQO1EGFRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0172632-B1 | Benzopyrano[4,3,2-cd]indazole compounds, processes for their production and pharmaceutical compositions comprising the compounds | WARNER-LAMBERT COMPANY (US) | 1989-08-30 | — | — | EP | disclosed |
| US-4604390-A | FUNGICIDES, ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY (US) | 1986-08-05 | — | — | US | disclosed |