⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL350244 | 0.76 | — | — | |
| SCHEMBL1320184 | 0.74 | — | — | |
| SCHEMBL16827844 | 0.73 | — | — | |
| SCHEMBL1027848 | 0.70 | — | — | |
| SCHEMBL62650 | 0.70 | — | — | |
| Tert-Butanol SCHEMBL28995626 | 0.70 | — | — | |
| SCHEMBL13015646 | 0.67 | — | — | |
| SCHEMBL18422351 | 0.67 | — | — | |
| SCHEMBL24869 | 0.67 | — | — | |
| Tert-Butanol SCHEMBL27559769 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023178130-A1 | SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2023-09-21 | — | — | WO | claimed |
| CN-114853812-A | Phosphine oxide group-containing compound, preparation method thereof and application thereof in medicine | 四川科伦博泰生物医药股份有限公司 | 2022-08-05 | — | — | CN | claimed |
| EP-2492266-B1 | 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2015-08-26 | — | — | EP | claimed |
| US-8785462-B2 | 5-hydroxypyrimidine-4-carboxamide derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-07-22 | — | — | US | claimed |
| US-20120220609-A1 | 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-08-30 | — | — | US | claimed |
| EP-2492266-A1 | 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2012-08-29 | — | — | EP | claimed |
| US-20230293702-A1 | QUINAZOLINES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2023-09-21 | — | — | US | disclosed |
| WO-2023178130-A1 | SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| CN-114853812-A | Phosphine oxide group-containing compound, preparation method thereof and application thereof in medicine | 四川科伦博泰生物医药股份有限公司 | 2022-08-05 | — | — | CN | disclosed |
| CN-102712619-B | 5-hydroxy pyrimidine-4-carboxamides derivatives | DAIICHI SANKYO Co.,Ltd. (JP) | 2015-11-25 | — | — | CN | disclosed |
| EP-2492266-B1 | 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2015-08-26 | — | — | EP | disclosed |
| US-8785462-B2 | 5-hydroxypyrimidine-4-carboxamide derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-07-22 | — | — | US | disclosed |
| US-20120220609-A1 | 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-08-30 | — | — | US | disclosed |
| EP-2492266-A1 | 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2012-08-29 | — | — | EP | disclosed |
| US-4847012-A | Vitamin D related compounds and processes for their preparation | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1989-07-11 | — | — | US | disclosed |