Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.52 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | JAK1 | P23458 | 3/20 | 0.48 |
| ▸ | TYK2 | P29597 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1050764 | 0.85 | JAK3 (0.54) | JAK3LCKJAK2JAK1TYK2 | |
| SCHEMBL1049584 | 0.85 | JAK3 (0.50) | JAK3LCKJAK2JAK1TYK2 | |
| SCHEMBL1045928 | 0.85 | JAK3 (0.50) | JAK3LCKJAK2JAK1TYK2 | |
| SCHEMBL1050011 | 0.82 | JAK3 (0.52) | JAK3LCKJAK2JAK1TYK2 | |
| SCHEMBL1048782 | 0.81 | JAK3 (0.59) | JAK3ENPP1LCK | |
| SCHEMBL1049059 | 0.80 | ROCK2 (0.55) | JAK3ENPP1JAK2JAK1TYK2 | |
| SCHEMBL1047339 | 0.77 | ROCK2 (0.46) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL1048032 | 0.76 | JAK3 (0.48) | JAK3LCKJAK2JAK1TYK2 | |
| SCHEMBL12500309 | 0.76 | JAK3 (0.53) | JAK3ENPP1LCKJAK2JAK1 | |
| SCHEMBL12500404 | 0.75 | JAK3 (0.57) | JAK3ENPP1LCKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451813-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | Leo Pharma A/S (DK) | 2012-05-16 | — | — | EP | claimed |
| WO-2011003418-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-01-13 | — | — | WO | claimed |
| EP-2451813-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | Leo Pharma A/S (DK) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011003418-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-01-13 | — | — | WO | disclosed |