Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 5/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.39 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 6/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1046300 | 0.89 | ALDH1A1 (0.51) | CLK4CYP1A2CYP3A4ALDH1A1ZAP70 | |
| SCHEMBL27806170 | 0.84 | ZAP70 (0.51) | CLK4CYP1A2CYP3A4ALDH1A1ZAP70 | |
| SCHEMBL1048387 | 0.83 | ZAP70 (0.73) | ZAP70TTBK1TTBK2JAK2STK3 | |
| SCHEMBL1048942 | 0.82 | ZAP70 (0.48) | ALDH1A1ZAP70LMNATTBK1TTBK2 | |
| SCHEMBL12928862 | 0.81 | ZAP70 (0.46) | ALDH1A1ZAP70LMNAMEN1KMT2A | |
| SCHEMBL1049582 | 0.79 | ZAP70 (0.73) | ZAP70JAK2JAK1AXLAURKA | |
| SCHEMBL1049635 | 0.76 | ZAP70 (0.53) | CLK4ZAP70TTBK1TTBK2MAPK14 | |
| SCHEMBL1047644 | 0.76 | ZAP70 (0.43) | ALDH1A1ZAP70LMNATTBK1TTBK2 | |
| SCHEMBL1045523 | 0.75 | JAK2 (0.49) | CLK4ZAP70TTBK1TTBK2MAPK14 | |
| SCHEMBL1048443 | 0.73 | ZAP70 (0.53) | CYP1A2CYP3A4ZAP70CYP2C19AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546370-B2 | Compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2013-10-01 | — | — | US | claimed |
| US-20110003798-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2011-01-06 | — | — | US | claimed |
| US-8546370-B2 | Compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2013-10-01 | — | — | US | disclosed |
| US-20110003798-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2011-01-06 | — | — | US | disclosed |
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003798-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | FYN, SYK, RET | CLK4 2379/4885CYP1A2 3670/4885CYP3A4 4175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.