Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373161 | 0.99 | DRD3 (0.54) | DRD3MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL7373158 | 0.81 | MEN1 (0.37) | DRD3MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL7376381 | 0.79 | DRD3 (0.77) | DRD3MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL31470970 | 0.77 | CYP3A4 (0.67) | DRD3MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL7369107 | 0.75 | DRD3 (0.58) | DRD3MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL7373985 | 0.74 | DRD3 (0.58) | DRD3MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL1501979 | 0.74 | HTR1A (0.60) | DRD3MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL3361901 | 0.74 | DRD3 (0.85) | DRD3MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL7369773 | 0.73 | DRD3 (0.77) | DRD3MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL27984721 | 0.70 | CYP3A4 (0.78) | DRD3MEN1KMT2ALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4870074-A | Substituted benzamide derivatives, for enhancing gastrointestinal motility | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |