Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19001159 | 0.90 | LMNA (0.53) | LMNAHPGDMEN1KMT2AKDM4E | |
| SCHEMBL14085921 | 0.90 | LMNA (0.53) | LMNAHPGDMEN1KMT2AKDM4E | |
| SCHEMBL1877827 | 0.87 | LMNA (0.51) | LMNAHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10906079 | 0.85 | ANPEP (0.47) | LMNAHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5554642 | 0.84 | LMNA (0.47) | LMNAHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20605974 | 0.83 | LMNA (0.46) | LMNAHPGDMEN1KMT2AKDM4E | |
| SCHEMBL20606341 | 0.83 | LMNA (0.46) | LMNAHPGDMEN1KMT2AKDM4E | |
| SCHEMBL20605972 | 0.83 | LMNA (0.46) | LMNAHPGDMEN1KMT2AKDM4E | |
| SCHEMBL23418190 | 0.81 | LMNA (0.45) | LMNAHPGDMEN1KMT2AKDM4E | |
| SCHEMBL28505561 | 0.81 | LMNA (0.45) | LMNAHPGDMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4820729-A | N-substituted-amido-amino acids | RORER PHARMACEUTICAL CORPORATION (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0071544-B1 | PHOSPHONAMIDATE COMPOUNDS | E.R. Squibb & Sons, Inc. (US) | 1986-10-08 | — | — | EP | disclosed |
| US-4432971-A | HYPOTENSIVE AGENTS AND ANGIOTENSIN INHIBITION | E. R. SQUIBB & SONS, INC. (US) | 1984-02-21 | — | — | US | disclosed |
| US-4432972-A | HYPOTENSIVE AGENTS, KANALGESICS, AND ANGIOTENSIN AND ENKEPHALIN INHIBITION | E. R. SQUIBB & SONS, INC. (US) | 1984-02-21 | — | — | US | disclosed |
| EP-0071544-A1 | Phosphonamidate compounds | E.R. Squibb & Sons, Inc. (US) | 1983-02-09 | — | — | EP | disclosed |