Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 16/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487556 | 1.00 | AKR1B1 (0.50) | AKR1B1MAPK1CYP2C19NPC1RAB9A | |
| SCHEMBL10487436 | 0.91 | AKR1B1 (0.54) | AKR1B1NPC1RAB9A | |
| SCHEMBL10715372 | 0.91 | AKR1B1 (0.54) | AKR1B1NPC1RAB9A | |
| SCHEMBL10580109 | 0.68 | AKR1B1 (0.56) | AKR1B1 | |
| SCHEMBL10571560 | 0.68 | AKR1B1 (0.56) | AKR1B1 | |
| SCHEMBL10487439 | 0.68 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1201316 | 0.67 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL9432020 | 0.67 | AKR1B1 (0.50) | AKR1B1NPC1RAB9A | |
| SCHEMBL9818973 | 0.67 | MAPK1 (0.40) | AKR1B1MAPK1CYP2C19NPC1RAB9A | |
| SCHEMBL9818970 | 0.67 | MAPK1 (0.40) | AKR1B1MAPK1CYP2C19NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| WO-1987004344-A1 | HYDROXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |