Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 18/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9433439 | 0.86 | AKR1B1 (0.48) | AKR1B1 | |
| SCHEMBL9433428 | 0.86 | AKR1B1 (0.48) | AKR1B1 | |
| SCHEMBL9433435 | 0.86 | AKR1B1 (0.48) | AKR1B1 | |
| SCHEMBL9432102 | 0.71 | AKR1B1 (0.56) | AKR1B1 | |
| SCHEMBL10487558 | 0.67 | AKR1B1 (0.50) | AKR1B1NPC1RAB9A | |
| SCHEMBL10487556 | 0.67 | AKR1B1 (0.50) | AKR1B1NPC1RAB9A | |
| SCHEMBL9432575 | 0.66 | AKR1B1 (0.46) | AKR1B1MAPT | |
| SCHEMBL9432149 | 0.65 | AKR1B1 (0.43) | AKR1B1MAPTNPC1RAB9A | |
| SCHEMBL4866087 | 0.61 | EPHX2 (0.45) | MAPTNPC1RAB9A | |
| SCHEMBL6237661 | 0.61 | EPHX2 (0.45) | MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294635-A | Heterocyclic compounds as aldose reductase inhibitors | PFIZER, INC. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0530198-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1991015491-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1991-10-17 | — | — | WO | disclosed |
| US-5039672-A | Administering enzyme inhibitors to control diabetes | PFIZER INC. (US) | 1991-08-13 | — | — | US | disclosed |