Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | APEX1 | P27695 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 7/20 | 0.63 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.61 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.58 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487926 | 0.92 | MEN1 (0.61) | HDAC1HDAC11HDAC8HDAC6APEX1 | |
| SCHEMBL10487897 | 0.91 | TSHR (0.62) | HDAC1HDAC11HDAC8HDAC6APEX1 | |
| SCHEMBL10487916 | 0.90 | MAPT (0.65) | HDAC1HDAC11HDAC8HDAC6APEX1 | |
| SCHEMBL18180338 | 0.89 | APEX1 (0.73) | APEX1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL13528242 | 0.88 | MAPT (0.78) | HDAC1HDAC11HDAC8HDAC6MAPT | |
| SCHEMBL10487872 | 0.87 | CCR2 (0.60) | HDAC1HDAC11HDAC8HDAC6APEX1 | |
| SCHEMBL10487857 | 0.87 | MAPT (0.64) | HDAC1HDAC11HDAC8HDAC6MAPT | |
| SCHEMBL2762171 | 0.86 | APEX1 (0.79) | HDAC1HDAC11HDAC8HDAC6APEX1 | |
| SCHEMBL10487958 | 0.86 | KDM4E (0.55) | HDAC1HDAC11HDAC8HDAC6MAPT | |
| SCHEMBL10487980 | 0.86 | MAPT (0.54) | HDAC1HDAC11HDAC8HDAC6APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4883800-A | DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-11-28 | — | — | US | disclosed |
| US-4734419-A | Quinazoline derivatives, compositions thereof and their use in treating diabetic complications | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0218999-A2 | New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |