Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7660613 | 0.85 | ALDH1A1 (0.49) | ALDH1A1KDM4ERAB9AMAPTTSHR | |
| SCHEMBL10487968 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KDM4ERAB9AMAPTTSHR | |
| SCHEMBL11261060 | 0.84 | TSHR (0.62) | APOBEC3AAPOBEC3GALDH1A1KMT2AKDM4E | |
| SCHEMBL10487991 | 0.80 | ALDH1A1 (0.46) | APOBEC3AAPOBEC3GALDH1A1KMT2AKDM4E | |
| SCHEMBL10487880 | 0.79 | ALDH1A1 (0.49) | ALDH1A1KMT2AKDM4ERAB9AMAPT | |
| SCHEMBL10487896 | 0.79 | MAPT (0.57) | ALDH1A1KMT2AKDM4ERAB9AMAPT | |
| SCHEMBL10487972 | 0.79 | KDM4E (0.62) | ALDH1A1KMT2AKDM4ERAB9ATSHR | |
| SCHEMBL8488837 | 0.78 | HDAC6 (0.53) | ALDH1A1KMT2AKDM4ERAB9AMAPT | |
| SCHEMBL10488076 | 0.78 | HDAC1 (0.53) | APOBEC3AAPOBEC3GALDH1A1KMT2AKDM4E | |
| SCHEMBL8487097 | 0.76 | MAPT (0.47) | KMT2AKDM4ERAB9AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4883800-A | DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-11-28 | — | — | US | disclosed |
| US-4734419-A | Quinazoline derivatives, compositions thereof and their use in treating diabetic complications | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0218999-A2 | New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |