Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 16/20 | 0.55 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1049017 | 0.97 | ZAP70 (0.54) | ZAP70AKT1BRD4JAK1JAK2 | |
| SCHEMBL3390899 | 0.90 | ZAP70 (0.60) | ZAP70JAK2 | |
| SCHEMBL1048533 | 0.88 | ZAP70 (0.69) | ZAP70JAK2 | |
| SCHEMBL13753099 | 0.85 | ZAP70 (0.54) | ZAP70JAK2 | |
| SCHEMBL1046622 | 0.83 | ZAP70 (0.67) | ZAP70JAK2 | |
| SCHEMBL27806093 | 0.79 | ZAP70 (0.60) | ZAP70JAK2 | |
| SCHEMBL1048405 | 0.79 | ZAP70 (0.63) | ZAP70JAK2 | |
| SCHEMBL1046645 | 0.78 | ZAP70 (0.70) | ZAP70JAK2 | |
| SCHEMBL1049742 | 0.77 | ZAP70 (0.69) | ZAP70JAK2 | |
| SCHEMBL1049197 | 0.76 | ZAP70 (0.60) | ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546370-B2 | Compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2013-10-01 | — | — | US | disclosed |
| US-20110003798-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003798-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | FYN, SYK, RET | ZAP70 4/4885AKT1 126/4885BRD4 2595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.