Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 17/20 | 0.60 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.38 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1048533 | 0.93 | ZAP70 (0.69) | ZAP70TTBK1TTBK2JAK2SYK | |
| SCHEMBL1048822 | 0.90 | ZAP70 (0.55) | ZAP70JAK2 | |
| SCHEMBL1049017 | 0.86 | ZAP70 (0.54) | ZAP70JAK2 | |
| SCHEMBL1046622 | 0.85 | ZAP70 (0.67) | ZAP70TTBK1TTBK2JAK2SYK | |
| SCHEMBL13753099 | 0.85 | ZAP70 (0.54) | ZAP70JAK2 | |
| SCHEMBL27806093 | 0.81 | ZAP70 (0.60) | ZAP70TTBK1TTBK2JAK2SYK | |
| SCHEMBL1046645 | 0.81 | ZAP70 (0.70) | ZAP70TTBK1TTBK2JAK2SYK | |
| SCHEMBL1048405 | 0.81 | ZAP70 (0.63) | ZAP70TTBK1TTBK2JAK2SYK | |
| SCHEMBL1049742 | 0.81 | ZAP70 (0.69) | ZAP70TTBK1TTBK2JAK2SYK | |
| SCHEMBL1049197 | 0.79 | ZAP70 (0.60) | ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |