SCHEMBL10488246

SCHEMBL10488246

CC(CO)(CO)NCc1c2ccccc2c(OCCO)c2ccccc12

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CD274 Q9NZQ7 2/20 0.40
CYP1A2 P05177 1/20 0.37
IDO1 P14902 1/20 0.36
KMT2A Q03164 2/20 0.35
ALDH1A1 P00352 1/20 0.35
RECQL P46063 1/20 0.35
NPBWR1 P48145 1/20 0.35
MCHR1 Q99705 1/20 0.35
SLC2A1 P11166 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
CYP3A4 P08684 1/20 0.34
PDCD1 Q15116 1/20 0.32
GAA P10253 1/20 0.32
TACR2 P21452 1/20 0.31
TACR3 P29371 1/20 0.31
MEN1 O00255 1/20 0.31
PDE9A O76083 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29449853 1.00 CD274 (0.40) CD274CYP1A2IDO1KMT2AALDH1A1
Hydrochloric Acid SCHEMBL10488206 0.99 CD274 (0.39) CD274CYP1A2IDO1KMT2AALDH1A1
SCHEMBL9465733 0.93 CD274 (0.37) CD274CYP1A2KMT2AALDH1A1NPBWR1
Hydrochloric Acid SCHEMBL9466527 0.92 CD274 (0.36) CD274CYP1A2KMT2AALDH1A1NPBWR1
SCHEMBL10488277 0.90 SLC2A1 (0.39) CD274CYP1A2KMT2ANPBWR1MCHR1
Hydrochloric Acid SCHEMBL10488368 0.89 SLC2A1 (0.39) CD274CYP1A2KMT2ANPBWR1MCHR1
SCHEMBL10488292 0.89 CD274 (0.39) CD274CYP1A2KMT2AALDH1A1NPBWR1
SCHEMBL10488302 0.87 CD274 (0.38) CD274CYP1A2KMT2AALDH1A1NPBWR1
SCHEMBL10488225 0.87 CD274 (0.37) CD274CYP1A2KMT2ANPBWR1MCHR1
Hydrochloric Acid SCHEMBL10488528 0.86 CD274 (0.38) CD274CYP1A2KMT2AALDH1A1NPBWR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4803226-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-02-07 US claimed
US-4719047-A ANTITUMOR BURROUGHS WELLCOME CO. (US) 1988-01-12 US claimed
EP-0125702-B1 POLYCYCLIC AROMATIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1987-08-12 EP claimed
US-4803226-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-02-07 US disclosed
US-4803221-A Anthracene derivatives BURROUGHS WELLCOME CO. (US) 1989-02-07 US disclosed
US-4719047-A ANTITUMOR BURROUGHS WELLCOME CO. (US) 1988-01-12 US disclosed
US-4719049-A ANTITUMOR BURROUGHS WELLCOME CO. (US) 1988-01-12 US disclosed
EP-0125702-B1 POLYCYCLIC AROMATIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1987-08-12 EP disclosed
EP-0125702-A2 Polycyclic aromatic compounds THE WELLCOME FOUNDATION LIMITED (GB) 1984-11-21 EP disclosed