SCHEMBL10488306

SCHEMBL10488306

C[S+]([O-])c1c2ccccc2c(C=O)c2ccccc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PADI4 Q9UM07 1/20 0.44
ERN1 O75460 3/20 0.36
ALDH1A1 P00352 4/20 0.35
LMNA P02545 3/20 0.35
CYP1A2 P05177 2/20 0.34
CYP2C19 P33261 2/20 0.34
MAPT P10636 2/20 0.34
CYP2C9 P11712 1/20 0.34
POLB P06746 1/20 0.33
KDM4E B2RXH2 2/20 0.33
THRB P10828 2/20 0.33
TDP1 Q9NUW8 3/20 0.32
GAA P10253 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
IMPDH2 P12268 1/20 0.32
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
UBE2N P61088 1/20 0.31
BLM P54132 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29588097 0.78 PADI4 (0.64) PADI4ERN1ALDH1A1LMNACYP1A2
SCHEMBL986883 0.78 PADI4 (0.64) PADI4ERN1ALDH1A1LMNACYP1A2
Iodide SCHEMBL9460922 0.75 PADI4 (0.61) PADI4ERN1ALDH1A1LMNACYP1A2
Bromide SCHEMBL11303999 0.75 PADI4 (0.61) PADI4ERN1ALDH1A1LMNACYP1A2
Hydrochloric Acid SCHEMBL9397561 0.75 PADI4 (0.61) PADI4ERN1ALDH1A1LMNACYP1A2
SCHEMBL4164444 0.72 PADI4 (0.52) PADI4ERN1ALDH1A1LMNACYP1A2
SCHEMBL29802335 0.72 PADI4 (0.52) PADI4ERN1ALDH1A1LMNACYP1A2
SCHEMBL1666387 0.70 PADI4 (0.61) PADI4ERN1ALDH1A1LMNACYP1A2
SCHEMBL9511557 0.70 PADI4 (0.68) PADI4ERN1ALDH1A1LMNACYP1A2
SCHEMBL10488224 0.68 PADI4 (0.48) PADI4ERN1ALDH1A1LMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4803226-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-02-07 US disclosed
US-4803221-A Anthracene derivatives BURROUGHS WELLCOME CO. (US) 1989-02-07 US disclosed
US-4719047-A ANTITUMOR BURROUGHS WELLCOME CO. (US) 1988-01-12 US disclosed
US-4719049-A ANTITUMOR BURROUGHS WELLCOME CO. (US) 1988-01-12 US disclosed
EP-0125702-B1 POLYCYCLIC AROMATIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1987-08-12 EP disclosed
EP-0125702-A2 Polycyclic aromatic compounds THE WELLCOME FOUNDATION LIMITED (GB) 1984-11-21 EP disclosed