Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.61 |
| ▸ | ERN1 | O75460 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29588097 | 0.97 | PADI4 (0.64) | PADI4ERN1MEN1KMT2ATDP1 | |
| SCHEMBL986883 | 0.97 | PADI4 (0.64) | PADI4ERN1MEN1KMT2ATDP1 | |
| Hydrochloric Acid SCHEMBL9397561 | 0.94 | PADI4 (0.61) | PADI4ERN1MEN1KMT2ATDP1 | |
| Bromide SCHEMBL11303999 | 0.94 | PADI4 (0.61) | PADI4ERN1MEN1KMT2ATDP1 | |
| SCHEMBL1666387 | 0.88 | PADI4 (0.61) | PADI4ERN1MEN1KMT2ATDP1 | |
| SCHEMBL9511557 | 0.88 | PADI4 (0.68) | PADI4ERN1MEN1KMT2ATDP1 | |
| SCHEMBL5750183 | 0.84 | PADI4 (0.52) | PADI4ERN1MEN1KMT2ATDP1 | |
| SCHEMBL1616239 | 0.84 | PADI4 (0.52) | PADI4ERN1MEN1KMT2ATDP1 | |
| SCHEMBL4164444 | 0.84 | PADI4 (0.52) | PADI4ERN1MEN1KMT2ATDP1 | |
| SCHEMBL11627970 | 0.84 | PADI4 (0.78) | PADI4ERN1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4258181-A | BACTERICIDES, AMTITUMOR AGENTS, ANTICARCINOGENIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1981-03-24 | — | — | US | claimed |
| US-5212291-A | Anthracycline derivatives as solubilized pro-drugs | AMERICAN CYANAMID COMPANY (US) | 1993-05-18 | — | — | US | disclosed |
| US-5116827-A | Antitumor agents | AMERICAN CYANAMID COMPANY (US) | 1992-05-26 | — | — | US | disclosed |
| US-5077283-A | Enhanced water and lipid solubility; antitumor, anticarcinogen ic agents | AMERICAN CYANAMID COMPANY (US) | 1991-12-31 | — | — | US | disclosed |
| US-5077282-A | Improved water or lipid solubility and reduced toxicity | AMERICAN CYANAMID COMPANY (US) | 1991-12-31 | — | — | US | disclosed |
| US-5070082-A | PHOSPHORYLATED DERIVATIVE OF PENTAMIDINE | AMERICAN CYANAMID COMPANY (US) | 1991-12-03 | — | — | US | disclosed |
| US-4900838-A | Acylation products of bis(2-imidazolin-2-ylhydrazones) of 9,10-anthracenedicarboxaldehyde | AMERICAN CYANAMID COMPANY (US) | 1990-02-13 | — | — | US | disclosed |
| EP-0338372-A2 | Solubilized pro-drugs | AMERICAN CYANAMID COMPANY (US) | 1989-10-25 | — | — | EP | disclosed |
| EP-0264901-A1 | Acylation products of bis(2-imidazolin-2-ylhydrazones) of 9,10-anthracenedicarboxaldehyde | AMERICAN CYANAMID COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |
| US-4258181-A | BACTERICIDES, AMTITUMOR AGENTS, ANTICARCINOGENIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1981-03-24 | — | — | US | disclosed |