Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7799400 | 0.88 | MAPT (0.55) | MAPTKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10435531 | 0.85 | ALDH1A1 (0.49) | MAPTKDM4EALDH1A1TDP1LMNA | |
| SCHEMBL18088093 | 0.84 | MAPT (0.54) | MAPTKDM4EALDH1A1TDP1LMNA | |
| SCHEMBL2839813 | 0.83 | MAPT (0.55) | MAPTKDM4EALDH1A1TDP1LMNA | |
| SCHEMBL28825735 | 0.82 | MAPT (0.55) | MAPTALDH1A1TDP1LMNASMN1; SMN2 | |
| SCHEMBL31327257 | 0.82 | MAPT (0.55) | MAPTALDH1A1TDP1LMNASMN1; SMN2 | |
| SCHEMBL4998777 | 0.82 | MAPT (0.56) | MAPTKDM4EALDH1A1TDP1LMNA | |
| SCHEMBL5212431 | 0.81 | MAPT (0.54) | MAPTKDM4EALDH1A1TDP1LMNA | |
| SCHEMBL215546 | 0.81 | CYP19A1 (0.54) | MAPTALDH1A1TDP1LMNASMN1; SMN2 | |
| SCHEMBL5550248 | 0.80 | PTGDR2 (0.57) | MAPTKDM4EALDH1A1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4873254-A | ADRENERGIC BLOCKING AGENTS OR CALCIUM CHANNEL BLOCKERS; HYPOTENSIVE AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-10-10 | — | — | US | disclosed |
| EP-0194751-A1 | Dihydropyridine alkanol amines, process for their preparation and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-09-17 | — | — | EP | disclosed |