Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.60 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.60 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.60 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | THPO | P40225 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11784675 | 0.86 | KMT2A (0.69) | HIF1AKMT2ACYP1A2ADORA3CYP3A4 | |
| SCHEMBL27869994 | 0.82 | KMT2A (0.55) | HIF1AKMT2ACYP1A2ADORA3CYP3A4 | |
| SCHEMBL11860028 | 0.82 | KMT2A (0.65) | HIF1AKMT2ACYP1A2ADORA3CYP3A4 | |
| SCHEMBL11784686 | 0.82 | KMT2A (0.65) | HIF1AKMT2ACYP1A2ADORA3CYP3A4 | |
| SCHEMBL8512764 | 0.82 | KMT2A (0.54) | HIF1AKMT2ACYP1A2ADORA3CYP3A4 | |
| SCHEMBL7160123 | 0.80 | ADORA3 (0.85) | HIF1AKMT2ACYP1A2ADORA3CYP3A4 | |
| SCHEMBL10692954 | 0.80 | ADORA3 (0.53) | HIF1AKMT2ACYP1A2ADORA3CYP3A4 | |
| SCHEMBL7882494 | 0.79 | TSHR (0.57) | KMT2AADORA3MAPTTSHRCACNA1F | |
| SCHEMBL7885521 | 0.79 | TSHR (0.57) | KMT2AADORA3MAPTTSHRLMNA | |
| SCHEMBL30648615 | 0.79 | HIF1A (0.87) | HIF1AKMT2ACYP1A2ADORA3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4873254-A | ADRENERGIC BLOCKING AGENTS OR CALCIUM CHANNEL BLOCKERS; HYPOTENSIVE AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-10-10 | — | — | US | disclosed |