Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 12/20 | 0.64 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.64 |
| ▸ | ADRB3 | P13945 | 17/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 10/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | FPR3 | P25089 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.54 |
| ▸ | HTR1B | P28222 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | GPR183 | P32249 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10488196 | 0.89 | ADRB2 (0.65) | ADRB2CHRM3ADRB3ADRB1KDM4E | |
| SCHEMBL10706286 | 0.88 | ADRB2 (0.66) | ADRB2CHRM3ADRB3ADRB1KDM4E | |
| SCHEMBL10488095 | 0.87 | ADRB2 (0.65) | ADRB2CHRM3ADRB3ADRB1KDM4E | |
| SCHEMBL10488114 | 0.86 | ADRB2 (0.62) | ADRB2CHRM3ADRB3ADRB1KDM4E | |
| SCHEMBL10488131 | 0.86 | ADRB3 (0.71) | ADRB2CHRM3ADRB3ADRB1 | |
| SCHEMBL10488200 | 0.85 | ADRB2 (0.62) | ADRB2CHRM3ADRB3ADRB1KDM4E | |
| SCHEMBL10488100 | 0.85 | ADRB3 (0.53) | ADRB2CHRM3ADRB3 | |
| SCHEMBL10488179 | 0.85 | ADRB2 (0.60) | ADRB2CHRM3ADRB3ADRB1KDM4E | |
| SCHEMBL10488537 | 0.84 | ADRB2 (0.61) | ADRB2CHRM3ADRB3ADRB1KDM4E | |
| SCHEMBL10866976 | 0.84 | ADRB2 (0.63) | ADRB2CHRM3ADRB3ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178919-B1 | AMINOPHENOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1988-12-21 | — | — | EP | claimed |
| EP-0178919-A2 | Aminophenol derivatives | GLAXO GROUP LIMITED (GB) | 1986-04-23 | — | — | EP | claimed |
| US-4853382-A | TREATING ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1989-08-01 | — | — | US | disclosed |
| US-4730008-A | STIMULANT FOR BETA-ADRENORECEPTORS | GLAXO GROUP LIMITED (GB) | 1988-03-08 | — | — | US | disclosed |
| EP-0178919-A2 | Aminophenol derivatives | GLAXO GROUP LIMITED (GB) | 1986-04-23 | — | — | EP | disclosed |