Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10488587 | 1.00 | SMN1; SMN2 (0.60) | SMN1; SMN2PDE4DLMNATSHRHSD17B10 | |
| SCHEMBL10488465 | 0.99 | SMN1; SMN2 (0.61) | SMN1; SMN2PDE4DLMNATSHRHSD17B10 | |
| SCHEMBL10488534 | 0.94 | SMN1; SMN2 (0.62) | SMN1; SMN2PDE4DLMNATSHRHSD17B10 | |
| SCHEMBL10488604 | 0.89 | SMN1; SMN2 (0.65) | SMN1; SMN2PDE4DLMNAAURKAMAPT | |
| SCHEMBL10488695 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2PDE4DLMNAPOLBGAA | |
| SCHEMBL10488600 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2PDE4DLMNAPOLBGAA | |
| SCHEMBL10978593 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2PDE4DLMNAAURKAMAPT | |
| SCHEMBL10488577 | 0.84 | SMN1; SMN2 (0.57) | SMN1; SMN2PDE4DLMNAHSD17B10AURKA | |
| Hydrochloric Acid SCHEMBL10488574 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2PDE4DLMNAHSD17B10AURKA | |
| SCHEMBL10488490 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2PDE4DLMNAPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315433-A2 | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-10 | — | — | EP | claimed |
| US-4826866-A | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-02 | — | — | US | claimed |