Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10488534 | 0.91 | SMN1; SMN2 (0.62) | SMN1; SMN2PDE4DAURKAMAPTPOLB | |
| SCHEMBL10488465 | 0.90 | SMN1; SMN2 (0.61) | SMN1; SMN2PDE4DAURKAMAPTPOLB | |
| SCHEMBL10488587 | 0.89 | SMN1; SMN2 (0.60) | SMN1; SMN2PDE4DAURKAMAPTPOLB | |
| SCHEMBL10488562 | 0.89 | SMN1; SMN2 (0.60) | SMN1; SMN2PDE4DAURKAMAPTPOLB | |
| SCHEMBL10488962 | 0.88 | SMN1; SMN2 (0.68) | SMN1; SMN2PDE4DAURKAMAPTPOLB | |
| SCHEMBL10488577 | 0.84 | SMN1; SMN2 (0.57) | SMN1; SMN2PDE4DAURKAMAPTPOLB | |
| SCHEMBL10489006 | 0.83 | PDE4D (0.67) | SMN1; SMN2PDE4DAURKAMAPTPOLB | |
| SCHEMBL10488470 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2PDE4DAURKAKDM4EGAA | |
| Hydrochloric Acid SCHEMBL10488574 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2PDE4DAURKAMAPTPOLB | |
| SCHEMBL10488922 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2PDE4DAURKAMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4826866-A | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-02 | — | — | US | claimed |
| EP-0315433-A2 | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-10 | — | — | EP | disclosed |