Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10488676 | 0.88 | MAPT (0.69) | MAPTPOLBSMN1; SMN2PDE4DRAB9A | |
| SCHEMBL10488958 | 0.86 | SMN1; SMN2 (0.59) | MAPTPOLBSMN1; SMN2PDE4DNPC1 | |
| SCHEMBL10488603 | 0.86 | POLB (0.55) | MAPTPOLBSMN1; SMN2PDE4DGAA | |
| SCHEMBL10488501 | 0.85 | POLB (0.66) | MAPTPOLBSMN1; SMN2PDE4DGAA | |
| SCHEMBL10488654 | 0.84 | MAPT (0.78) | MAPTPOLBSMN1; SMN2PDE4DNPC1 | |
| SCHEMBL10488614 | 0.83 | SMN1; SMN2 (0.56) | MAPTPOLBSMN1; SMN2PDE4DNPC1 | |
| SCHEMBL10488955 | 0.83 | MAPT (0.64) | MAPTPOLBSMN1; SMN2PDE4DGAA | |
| SCHEMBL10515210 | 0.83 | MAPT (0.46) | MAPTPOLBSMN1; SMN2NPC1MEN1 | |
| SCHEMBL10488775 | 0.82 | SMN1; SMN2 (0.70) | MAPTPOLBSMN1; SMN2PDE4DNPC1 | |
| SCHEMBL10488475 | 0.81 | POLB (0.55) | MAPTPOLBSMN1; SMN2PDE4DRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315433-A2 | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-10 | — | — | EP | claimed |
| US-4826866-A | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-02 | — | — | US | claimed |
| EP-0315433-A2 | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-10 | — | — | EP | disclosed |