Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SLC26A6 | Q9BXS9 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10488501 | 0.88 | POLB (0.66) | MAPTPOLBSMN1; SMN2PDE4DKMT2A | |
| SCHEMBL10488579 | 0.88 | MAPT (0.66) | MAPTPOLBSMN1; SMN2PDE4DKMT2A | |
| SCHEMBL10488654 | 0.86 | MAPT (0.78) | MAPTPOLBSMN1; SMN2PDE4DHPGD | |
| SCHEMBL10488955 | 0.85 | MAPT (0.64) | MAPTPOLBSMN1; SMN2PDE4DHPGD | |
| SCHEMBL10488647 | 0.85 | MAPT (0.57) | MAPTPOLBSMN1; SMN2PDE4DHPGD | |
| SCHEMBL10488775 | 0.84 | SMN1; SMN2 (0.70) | MAPTPOLBSMN1; SMN2PDE4DHPGD | |
| SCHEMBL10488475 | 0.83 | POLB (0.55) | MAPTPOLBSMN1; SMN2PDE4DHPGD | |
| SCHEMBL10488504 | 0.82 | KMT2A (0.57) | MAPTPOLBSMN1; SMN2HPGDKMT2A | |
| SCHEMBL10488614 | 0.81 | SMN1; SMN2 (0.56) | MAPTPOLBSMN1; SMN2PDE4DKMT2A | |
| SCHEMBL10565068 | 0.80 | SMN1; SMN2 (0.61) | MAPTPOLBSMN1; SMN2PDE4DKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4826866-A | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-02 | — | — | US | claimed |