Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10488490 | 0.95 | SMN1; SMN2 (0.45) | SMN1; SMN2CSNK2A2KDRCSNK2BCSNK2A1 | |
| SCHEMBL10488695 | 0.94 | SMN1; SMN2 (0.44) | SMN1; SMN2CSNK2A2KDRCSNK2BCSNK2A1 | |
| SCHEMBL10488600 | 0.94 | SMN1; SMN2 (0.44) | SMN1; SMN2CSNK2A2KDRCSNK2BCSNK2A1 | |
| SCHEMBL10488470 | 0.90 | SMN1; SMN2 (0.48) | SMN1; SMN2CSNK2A2KDRCSNK2BCSNK2A1 | |
| SCHEMBL10978593 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2CSNK2A2KDRCSNK2BCSNK2A1 | |
| SCHEMBL10488534 | 0.84 | SMN1; SMN2 (0.62) | SMN1; SMN2GAAPOLBLMNAPDE4D | |
| SCHEMBL10488456 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2GAAPOLBLMNAPDE4D | |
| SCHEMBL10488465 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2GAAPOLBLMNAPDE4D | |
| SCHEMBL10488562 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2GAAPOLBLMNAPDE4D | |
| SCHEMBL10488587 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2GAAPOLBLMNAPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4871737-A | 3-Amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0315433-A2 | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-10 | — | — | EP | disclosed |
| US-4826866-A | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-02 | — | — | US | disclosed |