Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM6 | O15303 | 8/20 | 0.76 |
| ▸ | TP53 | P04637 | 8/20 | 0.55 |
| ▸ | MDM2 | Q00987 | 8/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6157860 | 0.85 | TP53 (0.75) | GRM6TP53MDM2GRM5ALDH1A1 | |
| SCHEMBL10489599 | 0.84 | GRM6 (0.54) | GRM6TP53MDM2ALDH1A1MAPT | |
| SCHEMBL10489630 | 0.84 | GRM6 (0.71) | GRM6TP53MDM2GRM5ALDH1A1 | |
| SCHEMBL4095490 | 0.83 | TP53 (0.56) | GRM6TP53MDM2GRM5ALDH1A1 | |
| SCHEMBL25758961 | 0.83 | GRM6 (0.76) | GRM6TP53MDM2GRM5ALDH1A1 | |
| SCHEMBL10489614 | 0.82 | TP53 (0.55) | GRM6TP53MDM2ALDH1A1MAPT | |
| SCHEMBL1899041 | 0.76 | PRKCZ (0.70) | GRM6ALDH1A1MAPTGAAHPGD | |
| SCHEMBL6613252 | 0.74 | TP53 (0.53) | GRM6TP53MDM2GRM5ALDH1A1 | |
| SCHEMBL10633454 | 0.74 | GRM6 (0.60) | GRM6GRM5ALDH1A1MAPTGAA | |
| SCHEMBL6159255 | 0.72 | GRM6 (0.78) | GRM6TP53MDM2GRM5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4859699-A | Substituted N-benzoyl-N'-thienylureas | SANDOZ LTD. (CH) | 1989-08-22 | — | — | US | disclosed |
| EP-0300972-A1 | Substituted N-benzoyl-N'-thienyl ureas, and their use as insecticides | SANDOZ AG (CH) | 1989-01-25 | — | — | EP | disclosed |